Can you get the MMR vaccine while on Cosentyx?
No, the MMR vaccine (measles, mumps, rubella) is not recommended during Cosentyx (secukinumab) treatment. Cosentyx suppresses the immune system by blocking IL-17A, increasing risks of infection and reducing vaccine effectiveness, especially for live vaccines like MMR.[1][2]
Why avoid live vaccines like MMR with Cosentyx?
Live vaccines contain weakened viruses that replicate in the body to build immunity. Immunosuppressants like Cosentyx can allow these viruses to cause active infection in vulnerable patients. The prescribing information explicitly advises against live vaccines during treatment and for up to 4-6 weeks after the last dose.[1][3]
What does the official Cosentyx guidance say?
Novartis, the manufacturer, states: "Live vaccines should not be given concurrently with COSENTYX." Update vaccinations before starting therapy if possible. For MMR specifically, complete it at least 4 weeks prior to initiating Cosentyx.[1]
Are inactivated vaccines safe instead?
Yes, inactivated or subunit vaccines (e.g., flu shot, Tdap, pneumococcal) are generally safe and recommended during Cosentyx use. They don't replicate, so immunosuppression poses less risk. Confirm with your doctor for personalized advice.[1][2]
What if I'm already on Cosentyx and need MMR?
Delay MMR until after stopping Cosentyx, waiting at least 4 weeks post-last dose. Antibody titers can check prior immunity. In emergencies (e.g., outbreak), consult an infectious disease specialist—weigh risks individually.[3][4]
Cosentyx alternatives for patients needing MMR
If MMR timing conflicts, doctors may pause Cosentyx briefly or switch to non-IL-17 biologics like Dupixent (dupilumab), which has fewer live vaccine restrictions. Psoriasis or psoriatic arthritis patients should discuss with rheumatologists or dermatologists.[2][5]
[1] Cosentyx Prescribing Information (Novartis)
[2] CDC: Immunosuppressants and Vaccines
[3] ACR Guidelines: Vaccinations in Rheumatic Diseases
[4] FDA: Secukinumab Label
[5] Dupixent Prescribing Information (Sanofi/Regeneron)