Does Cosentyx (secukinumab) suppress the immune system?
Cosentyx can affect parts of the immune system because it blocks interleukin-17A (IL-17A), a signal involved in inflammation. By targeting that pathway, it can make some patients more susceptible to certain infections, even though it is not described as a broad “knockdown” of the immune system like some older immunosuppressants.
What kinds of infections are patients told to watch for?
Common safety counseling with IL-17 blockers like Cosentyx focuses on infections, particularly:
- Upper respiratory infections (such as colds)
- Fungal infections, especially mucocutaneous (skin and mouth/thrush-type) infections
If you develop signs of infection (for example, fever, worsening cough, or persistent thrush-like symptoms), clinicians typically advise contacting the prescribing team promptly.
Can Cosentyx make you more likely to get serious infections?
The main concern is an increased risk of infections in general compared with placebo, with clinicians paying extra attention to people who already have higher infection risk (for example, frequent infections, chronic infections, or other immunosuppressing therapies). Whether your personal risk is higher depends on your health history and what other medicines you take.
Does it increase the risk of tuberculosis or hepatitis?
Biologics that change immune signaling are often screened for infections like tuberculosis before starting and monitored as needed. Your prescriber will generally check your TB status and review hepatitis risk based on your history and local guidance.
What about vaccines—can you still get them?
Because Cosentyx modifies immune signaling, vaccine timing and type matters. In many biologic treatments:
- Non-live vaccines are usually considered safe (but may work less strongly).
- Live vaccines are often avoided while on therapy.
Your clinician can advise which vaccines you can take and when.
Who should be extra cautious?
Risk tends to be higher if you have:
- A current active infection
- A history of recurrent or chronic infections
- Conditions that already weaken immunity
- Use of other immune-suppressing medications
If any of those apply, it’s important to discuss infection-prevention steps with your prescriber before and during treatment.
How to reduce infection risk while on Cosentyx
Practical steps typically include:
- Don’t start Cosentyx during an active infection.
- Report fever or symptoms early.
- Follow screening requirements (like TB testing) before starting.
- Keep up with recommended vaccines using the right types.
If you tell me what condition you’re taking Cosentyx for (psoriasis, psoriatic arthritis, ankylosing spondylitis, etc.) and whether you have other immune-related conditions or take other immunosuppressants, I can help you understand what “immune lowering” means for your specific situation.