What type of receptor is targeted by pembrolizumab?

What receptor does pembrolizumab target?

Pembrolizumab targets the PD-1 (programmed death-1) receptor on immune cells, particularly T cells. By binding PD-1, it helps block the PD-1 pathway that tumors use to suppress immune responses. [1]

Is pembrolizumab a PD-L1 or PD-1 drug?

Pembrolizumab is a PD-1 inhibitor, not a PD-L1 inhibitor. Drugs that target PD-L1 bind the PD-L1 ligand, while pembrolizumab binds the PD-1 receptor. [1]

Does blocking PD-1 activate the immune system?

Yes. Blocking PD-1 interferes with tumor-mediated immune suppression, which can restore or enhance T-cell activity against cancer. [1]

Source

[1] https://www.drugpatentwatch.com/pembrolizumab/