Can Colcrys (colchicine) cause diarrhea?
Yes. Colcrys (colchicine) can cause gastrointestinal side effects, and diarrhea is one of the commonly reported effects. [1]
Is diarrhea a sign of overdose or toxicity?
Diarrhea can also be an early sign of colchicine toxicity, especially if the dose is too high or if the drug builds up due to reduced kidney or liver function, certain drug interactions, or older age. If diarrhea is severe, persistent, or comes with other symptoms such as vomiting, abdominal pain, weakness, or easy bruising/bleeding, seek medical care right away. [1]
What should patients do if they develop diarrhea on Colcrys?
Stop and get medical advice promptly if the diarrhea is significant or not improving, since the next step may include dose adjustment or holding the medication. Contact a clinician urgently if symptoms suggest toxicity (severe diarrhea, dehydration, or additional concerning signs). [1]
What increases the risk?
The risk of GI side effects and toxicity is higher when colchicine exposure increases, such as with:
- kidney or liver problems
- drug interactions that raise colchicine levels
- taking higher-than-prescribed doses [1]
Source
[1] https://www.drugs.com/colcrys.html