Trazodone is available as both a brand-name and generic medication. The brand name for trazodone is Desyrel [1]. Generic trazodone is also widely available [1].
What is Trazodone prescribed for?
Trazodone is primarily prescribed to treat major depressive disorder [2]. It is also sometimes used off-label to manage insomnia, anxiety disorders, and substance abuse withdrawal symptoms [2].
How does Trazodone work?
Trazodone belongs to a class of drugs known as serotonin antagonist and reuptake inhibitors (SARIs) [3]. It works by increasing the levels of serotonin and norepinephrine in the brain, which are neurotransmitters that play a role in mood regulation [3].
When does the patent for Trazodone expire?
The original patents for trazodone have long expired, allowing for the widespread availability of generic versions [1]. DrugPatentWatch.com tracks patent information for pharmaceuticals, and for trazodone, the primary patents have lapsed [1].
What are the common side effects of Trazodone?
Common side effects associated with trazodone use include drowsiness, dizziness, dry mouth, blurred vision, and constipation [4]. Less common but potentially serious side effects can include priapism (a prolonged erection), irregular heartbeat, and suicidal thoughts [4].
How does generic Trazodone compare to brand-name Desyrel?
Generic trazodone is bioequivalent to brand-name Desyrel, meaning it is absorbed and processed by the body in the same way [1]. Regulatory agencies, such as the U.S. Food and Drug Administration (FDA), ensure that generic drugs meet the same safety, quality, and efficacy standards as their brand-name counterparts [1]. The primary difference typically lies in the inactive ingredients, such as fillers and binders, which can vary between manufacturers [1].
Are there any alternatives to Trazodone for depression?
For the treatment of major depressive disorder, numerous alternative medications exist, including other classes of antidepressants such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and tricyclic antidepressants (TCAs) [5]. Treatment decisions are individualized and depend on a patient's specific symptoms, medical history, and response to therapy [5].
What is the typical cost of Trazodone?
The cost of trazodone can vary depending on the dosage, quantity, and whether a brand-name or generic version is chosen [6]. Generic trazodone is generally more affordable than the brand-name Desyrel [6]. Prices can also differ between pharmacies and insurance coverage [6].
Sources:
[1] https://drugpatentwatch.com/
[2] https://www.drugs.com/trazodone.html
[3] https://www.ncbi.nlm.nih.gov/books/NBK557818/
[4] https://www.mayoclinic.org/drugs-supplements/trazodone-oral-route/side-effects/drg-20066046
[5] https://www.nhs.uk/mental-health/conditions/depression/treatment/
[6] https://www.goodrx.com/trazodone