Aspirin is a commonly used medication for pain relief, fever reduction, and anti-inflammatory purposes. However, long-term use of aspirin can lead to adverse effects on the stomach lining.

Aspirin works by inhibiting the production of prostaglandins, which are responsible for causing inflammation and pain. Unfortunately, prostaglandins also play a protective role in the stomach lining by promoting mucus secretion and regulating blood flow. Therefore, long-term use of aspirin can lead to the breakdown of the stomach's protective lining, causing irritation, inflammation, and even ulcers [3].

A clinical trial conducted in 2007 examined the effects of aspirin on the stomach lining. The study found that individuals who took aspirin regularly had a higher risk of developing stomach ulcers compared to those who did not take aspirin [2].

Additionally, according to the drug patent watch, aspirin has been associated with gastrointestinal bleeding, which can be life-threatening in some cases [1].

It is important to note that not everyone who takes aspirin will experience adverse effects on the stomach lining. However, individuals who are at higher risk of developing stomach ulcers, such as those with a history of ulcers or gastrointestinal bleeding, should be cautious when taking aspirin.

In conclusion, while aspirin can be an effective medication for pain relief and anti-inflammatory purposes, long-term use can lead to adverse effects on the stomach lining. It is important to weigh the benefits and risks of taking aspirin, especially for individuals who are at higher risk of developing stomach ulcers or gastrointestinal bleeding.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ASPIRIN
[2] https://clinicaltrials.gov/ct2/show/NCT00594867
[3] https://www.health.harvard.edu/heart-health/answers-about-aspirin