Do you want a list of US patent applications that have claims on arginine biosynthesis, or would you prefer a high‑level overview of typical US claim scopes in this area (and how to search for them)? I can help with either.
Here’s a quick starter to help you search and understand the landscape:
What US claims on arginine biosynthesis typically cover
- Methods of producing L-arginine by fermentation using recombinant or engineered microorganisms that increase flux to arginine.
- Engineered host cells or microorganisms with modifications to arginine biosynthesis genes (e.g., upregulating the pathway, or removing feedback inhibition) to boost arginine production.
- Strains or cell lines engineered for higher arginine titer, rate, or yield, often described with specific genetic changes (gene names like argA, argB, argC, argD, argE, argF, argR, and related regulatory elements).
- Product-by-process or process claims for arginine produced by fermentation, including downstream recovery/purification steps and sometimes specific culture conditions (media, pH, temperature, agitation, feed strategies).
- Compositions or methods that include particular fermentation setups, purification schemes, or scale‑up aspects for arginine production.
How to search (practical approach)
- Use Google Patents (google.com/patents) and filter to US patent documents.
- Try search strings such as:
- "L-arginine production fermentation US patent"
- "arginine biosynthesis US patent application"
- "recombinant microorganism arginine production US patent"
- "Corynebacterium arginine production US patent" (common production hosts)
- Use USPTO PatFT PatDials (patft.uspto.gov) for US applications and issued patents; search by:
- Keywords: "arginine production", "arginine biosynthesis", "L-arginine", "fermentation"
- Assignees (if known): major amino acid producers often appear (e.g., Ajinomoto, CJ CheilJedang, Evonik, DSM, etc.)
- Inventor keywords: metabolism, arginine, biosynthesis, fermentation
- Broaden with related terms if needed:
- “host cell overproduces arginine”
- “arginine biosynthetic pathway engineering”
- “arginine titer” and “yield” in claims
- Look for families and US continuations/diversity:
- Identify a few US published applications and then check their family members for corresponding international filings to understand the scope.
- What to extract if you’re reviewing:
- Independent claim language (what is claimed at a high level)
- Key limitations (host organism, which genes/pathway elements are modified, production metrics like titer/yield/productivity)
- Any product-by-process limitations or purification steps
- Specific culture conditions if claimed
Example independent-claim skeletons you might see
- A recombinant microorganism engineered to overproduce L-arginine, comprising at least one genetic modification in a gene selected from the arginine biosynthesis cluster (e.g., argA, argB, argC, argD, argE, argF, argR) such that production of L-arginine is increased relative to a wild-type organism.
- A method for producing L-arginine comprising: culturing a recombinant microorganism of the above type under conditions that support growth and arginine production, and recovering L-arginine from the culture.
- A host cell comprising a plasmid or genome modification that directs increased flux through the arginine biosynthetic pathway to yield increased L-arginine, with specifications on titer/yield if claimed.
- A fermentation medium or process (pH, temperature, carbon source, feeding strategy) that enables enhanced L-arginine production by the engineered organism, claimed in combination with the genetic modifications.
If you want, I can help you do a targeted, quick scan and compile:
- A list of US published applications (with publication numbers) that have arginine biosynthesis or arginine production in the claims
- Any granted US patents that claim arginine biosynthesis or production
- Quick notes on claim breadth and typical claim language
Tell me:
- Do you want only US published applications or both grants and applications?
- Any preferred time frame or assignees?
- Do you want only high-level summaries or actual claim wording highlights?
Note: I can help with search strategy and general interpretation, but for legal conclusions or freedom-to-operate analysis you should consult a patent attorney.