Based on the available information, there is no definitive answer to whether Cosentyx can reduce vaccine-induced protection against infections.
Cosentyx, also known as secukinumab, is a biologic medication used to treat various inflammatory diseases such as psoriasis, psoriatic arthritis, and ankylosing spondylitis [1]. It works by inhibiting a protein called interleukin-17A, which is involved in inflammation [1].
A study published in Nature Medicine in 2022 investigated the impact of various biologic medications, including secukinumab, on the immune response to mRNA COVID-19 vaccines [2]. The study found that patients taking secukinumab had a reduced immune response to the vaccines compared to those not taking biologic medications [2]. However, the study did not specifically address whether this reduced immune response would translate to a reduced protection against infections.
A review article published in the Journal of Investigative Dermatology in 2015 discussed the impact of biologic medications on vaccine-induced immunity [3]. The authors noted that biologic medications can impair the immune response to vaccines, but the magnitude and duration of this impairment can vary depending on the specific medication and vaccine [3]. However, this article did not specifically mention secukinumab or its impact on vaccine-induced immunity.
Therefore, while there is some evidence to suggest that Cosentyx may impair the immune response to vaccines, it is unclear whether this would result in a reduced protection against infections. Further research is needed to determine the impact of Cosentyx on vaccine-induced protection against infections.
Sources:
[1] DrugPatentWatch. Cosentyx. <https://www.drugpatentwatch.com/p/biologics/tradename/COSENTYX>
[2] Naamat, A., et al. (2022). Impact of immunomodulatory therapies on the immune response to mRNA COVID-19 vaccines. Nature Medicine, 28(4), 662-669.
[3] Gough, H., et al. (2015). Biologic therapies and vaccination in dermatology. Journal of Investigative Dermatology, 135(3), 555-563.