The recommended dosage of lacosamide can vary depending on the specific condition being treated and individual patient factors. Lacosamide is an antiepileptic drug used to control seizures in patients with epilepsy.
According to the Drug Patent Watch website, the recommended starting dose of lacosamide for adults with partial-onset seizures is usually 50 mg twice daily, which can be increased gradually to a maximum dose of 400 mg per day [1]. The website also mentions that the recommended starting dose for pediatric patients (4 years and older) with partial-onset seizures is 1 mg/kg twice daily, not exceeding 400 mg per day [1].
The Mayo Clinic provides similar information regarding the dosage of lacosamide for adults. They state that the usual starting dose is 50 mg twice daily, which can be increased by 100 mg per day every week until an effective dose is reached. The maximum recommended dose is 400 mg per day [2].
A study published in the journal Clinical Drug Investigation, which is cited in the National Center for Biotechnology Information (NCBI) database, evaluated the efficacy and safety of lacosamide in patients with epilepsy. The study mentions that the starting dose of lacosamide for adults is typically 100 mg per day, which can be increased to a maximum of 400 mg per day based on individual response and tolerability [3].
It is important to note that the recommended dosage may vary for different patient populations and medical conditions. Therefore, it is crucial to consult with a healthcare professional who can provide personalized dosing instructions based on the specific needs of the patient.
In summary, the recommended dosage of lacosamide for adults with partial-onset seizures is typically 50 mg twice daily, gradually increasing to a maximum of 400 mg per day. The starting dose for pediatric patients is 1 mg/kg twice daily, not exceeding 400 mg per day. However, individual dosing may vary, and it is essential to consult with a healthcare professional for personalized dosing instructions.
Sources:
[1] Drug Patent Watch. (n.d.). Lacosamide. Retrieved from https://www.drugpatentwatch.com/p/tradename/LACOSAMIDE
[2] Mayo Clinic. (2021). Lacosamide (Oral Route): Proper Use. Retrieved from https://www.mayoclinic.org/drugs-supplements/lacosamide-oral-route/proper-use/drg-20072409
[3] National Center for Biotechnology Information. (2021). Efficacy and Safety of Lacosamide in Patients with Epilepsy: A Systematic Review and Meta-Analysis. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408586/