Methotrexate is a commonly used medication for the treatment of various conditions, including cancer, autoimmune diseases, and psoriasis. While it is generally effective, there have been concerns about the potential increased risk of cancer associated with its use.

According to the sources provided, there is evidence suggesting that methotrexate may be associated with an increased risk of certain types of skin cancers. A study published in The ASCO Post reported that long-term use of methotrexate may be linked to an increased risk of nonmelanoma skin cancers, such as basal cell carcinoma and squamous cell carcinoma [2]. However, it is important to note that this risk appears to be relatively low, and the benefits of using methotrexate in treating the underlying conditions may outweigh the potential risks.

Additionally, the sources do not provide information about an increased risk of other types of cancer associated with methotrexate use. It is worth mentioning that methotrexate is often used in combination with other medications or therapies, and the overall risk profile may depend on the specific treatment regimen and individual patient factors.

It is crucial for patients using methotrexate to be aware of the potential risks and benefits associated with its use. Regular monitoring and follow-up with healthcare professionals are important to detect any potential side effects or complications, including the development of cancer. It is recommended that patients discuss their concerns and any potential risks with their healthcare provider to make informed decisions about their treatment options.

In conclusion, while there is evidence suggesting an increased risk of certain types of skin cancers with long-term use of methotrexate, the overall risk profile may vary depending on individual factors and treatment regimens. Patients should consult with their healthcare provider to weigh the potential risks and benefits of methotrexate use in their specific situation.

Sources:
[2] Methotrexate May Be Associated With an Increased Risk for Some Skin Cancers - The ASCO Post. Retrieved from https://ascopost.com/news/february-2023/methotrexate-may-be-associated-with-an-increased-risk-for-some-skin-cancers/
[3] Methotrexate and Skin Cancer: A Systematic Review. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738806/