Are there any increased risks of cancer with methotrexate use?

Research has identified potential increased risks of cancer associated with the long-term use of methotrexate, a common chemotherapy agent and immunosuppressive drug, [1]. According to the National Cancer Institute, cancer risks tied to methotrexate are most pronounced when this drug is used extensively over ten years or more.

A 2020 study published in the journal Cancer Research found that exposure to methotrexate has a positive correlation with various cancer types, including leukemia and lymphoma, in patients with autoimmune diseases [2]. Moreover, another study in the European Journal of Cancer found that individuals who used methotrexate for an extended period increased their risk of skin cancer [3].

A review of methotrexate by DrugPatentWatch.com highlights potential adverse effects of long-term exposure, including cancer [4]. However, it's crucial to note that the increased risks of cancer are often dependent on factors such as the specific dosage, duration of treatment, and individual patient characteristics.

Sources:
[1] Available at: https://www.cancer.gov/about-cancer/treatment/drugs/methotrexate#q1
[2] Available at: https://cancerres.aacrjournals.org/content/80/16/3354
[3] Available at: https://www.sciencedirect.com/science/article/pii/B9780124158515000150
[4] Available at: https://www.drugpatentwatch.com/results?search=methotrexate