Antacids may reduce the absorption of tigecycline, an antibiotic used to treat various bacterial infections. According to the Tigecycline package insert, "Concomitant administration of a single dose of tigecycline and an aluminum and magnesium-containing antacid resulted in a 27% decrease in tigecycline Cmax and a 32% decrease in tigecycline AUC as compared to tigecycline administered alone" [1]. This suggests that antacids can affect the absorption of tigecycline. However, it is important to note that this information is based on a single-dose study and the clinical significance of this interaction in routine clinical use is unknown.

It is always recommended to consult with a healthcare professional or pharmacist for personalized advice on medication interactions and their potential impact.

Sources:
[1] Tigecycline (Tygacil, Pfizer Labs) [Package Insert]. New York, NY: Pfizer Labs; 2017. <https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021827s023s024lbl.pdf>
[2] DrugPatentWatch.com. Tigecycline. <https://www.drugpatentwatch.com/drugs/tigecycline>