Benadryl and Lipitor are two different medications that are used to treat different conditions. Benadryl is an antihistamine that is used to treat allergies, while Lipitor is a medication that is used to lower cholesterol levels in the blood.

According to the sources provided, there is no direct evidence that suggests that Benadryl can worsen the side effects of Lipitor. However, it is important to note that both medications can cause drowsiness, dizziness, and confusion, which can be dangerous if you are driving or operating heavy machinery. Therefore, it is recommended to avoid taking Benadryl and Lipitor together unless it is absolutely necessary and under the guidance of a healthcare professional.

It is also important to note that Benadryl can interact with other medications, such as antidepressants, sedatives, and muscle relaxants, which can increase the risk of side effects. Additionally, Benadryl can cause nightmares and disturbing dreams, which can be a concern for some individuals.

In conclusion, there is no direct evidence that suggests that Benadryl can worsen the side effects of Lipitor. However, both medications can cause drowsiness, dizziness, and confusion, which can be dangerous. It is recommended to avoid taking Benadryl and Lipitor together unless it is absolutely necessary and under the guidance of a healthcare professional. It is also important to be aware of the potential interactions and side effects of Benadryl and to consult with a healthcare professional if you have any concerns.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/BENADRYL
[2] https://www.buzzrx.com/blog/medications-that-should-never-be-combined-with-benadryl
[3] https://www.goodrx.com/drugs/side-effects/medications-that-cause-nightmares-and-disturbing-dreams