Lipitor is a medication used to lower cholesterol levels in the body. According to the sources provided, there is no indication that taking Lipitor with a high-fat diet is unsafe. However, it is important to note that a high-fat diet can increase cholesterol levels, which may make it more difficult for Lipitor to effectively lower cholesterol levels.

Lipitor works by inhibiting an enzyme in the liver that is responsible for producing cholesterol. It is typically prescribed along with lifestyle changes such as a healthy diet and exercise. The drug patent watch [1] states that Lipitor is effective in reducing cholesterol levels in the body.

A study published in PubMed [2] investigated the effects of a high-fat diet on the efficacy of Lipitor. The study found that a high-fat diet did not significantly affect the ability of Lipitor to lower cholesterol levels. However, the study also noted that a high-fat diet can increase cholesterol levels, which may make it more difficult for Lipitor to effectively lower cholesterol levels.

WebMD [3] provides information on Lipitor, including its uses, dosage, side effects, and precautions. The website recommends that individuals taking Lipitor should follow a healthy diet and exercise regularly to help lower cholesterol levels.

In conclusion, there is no indication that taking Lipitor with a high-fat diet is unsafe. However, it is important to note that a high-fat diet can increase cholesterol levels, which may make it more difficult for Lipitor to effectively lower cholesterol levels. Individuals taking Lipitor should follow a healthy diet and exercise regularly to help lower cholesterol levels.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://pubmed.ncbi.nlm.nih.gov/21269482/
[3] https://www.webmd.com/drugs/2/drug-3330/lipitor-oral/details