Advil is a brand name for the drug ibuprofen, which is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce fever, and reduce inflammation [2]. It works by blocking the production of certain chemicals in the body that cause pain and inflammation. While Advil is generally safe and effective when used as directed, there are some potential long-term effects to be aware of.

One of the main concerns with long-term use of Advil is the risk of gastrointestinal (GI) bleeding and ulcers. NSAIDs can irritate the lining of the stomach and intestines, leading to inflammation, ulcers, and bleeding [2]. This risk is higher in people who are older, have a history of GI problems, or take high doses of Advil for long periods of time [3]. To reduce this risk, it is recommended to take the lowest effective dose of Advil for the shortest amount of time possible [2].

Another potential long-term effect of Advil is kidney damage. NSAIDs can reduce blood flow to the kidneys and cause damage to the kidneys over time [2]. This risk is higher in people who have pre-existing kidney problems, are older, or take high doses of Advil for long periods of time [3]. To reduce this risk, it is recommended to drink plenty of fluids while taking Advil and to avoid taking it for long periods of time [2].

In addition to these potential long-term effects, there are also some common side effects of Advil that can occur with short-term or long-term use. These include nausea, vomiting, stomach pain, headache, dizziness, and drowsiness [3]. If these side effects persist or worsen, it is important to contact a healthcare provider.

In conclusion, while Advil is generally safe and effective when used as directed, there are some potential long-term effects to be aware of. These include the risk of GI bleeding and ulcers and kidney damage. To reduce these risks, it is recommended to take the lowest effective dose of Advil for the shortest amount of time possible and to drink plenty of fluids while taking it. It is also important to be aware of common side effects and to contact a healthcare provider if they persist or worsen.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://adf.org.au/drug-facts/ibuprofen/
[3] https://www.goodrx.com/advil/advil-side-effects