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How does Lipitor compare to Zocor for lowering cholesterol? Both Lipitor (atorvastatin) and Zocor (simvastatin) belong to the statin class of drugs. They work by blocking HMG-CoA reductase, the enzyme that produces cholesterol in the liver. [1] The drugs reduce LDL cholesterol levels and reduce cardiovascular risk. Lipitor reduces LDL cholesterol by 39% to 60%, depending on the dose. Zocor reduces LDL by 28% to 41%. [1] Lipitor has a longer half-life, 14 hours compared to 3 hours for Zocor, so it stays active in the body for longer. [1] How does this medicated approach affect daily life? Patients report taking Lipitor at any time of day, whereas Zocor must be taken in the evening because it has a short half-life. [1] Patients who prefer consistent dosing schedules may choose Lipitor. What happens if you switch from Lipitor to Zocor? Switching from Lipitor to Zocor may cause LDL levels to rise if the doses are not matched properly. [1]<|eos|>
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