See the DrugPatentWatch profile for Dexlansoprazole
Dexlansoprazole delayed release capsules are a proton pump inhibitor (PPI) used to treat heartburn and other symptoms of gastroesophageal reflux disease (GERD) [1]. They work by reducing the amount of acid produced in the stomach [1]. The delayed-release formulation means the capsule is designed to release the medication at a specific time in the digestive tract [2].
What is Dexlansoprazole used for?
Dexlansoprazole is prescribed to heal erosive esophagitis, a condition where acid reflux damages the lining of the esophagus [1]. It is also used for the maintenance treatment of healed erosive esophagitis and for symptomatic GERD in adults [1].
How does Dexlansoprazole work?
As a proton pump inhibitor, dexlansoprazole targets the H+/K+ ATPase enzyme system, also known as the proton pump, in the stomach lining [1]. By inhibiting this pump, it effectively decreases gastric acid secretion [1]. The delayed-release capsules are designed with a dual delayed-release technology, which releases the active ingredient at two different times in the gastrointestinal tract [3]. This may lead to a more sustained release of the drug [3].
When does patent protection for Dexlansoprazole expire?
Information on the specific patent expiry dates for dexlansoprazole is typically tracked by specialized services [4]. DrugPatentWatch.com is a resource that provides detailed patent information for pharmaceutical products, including expiry dates, patent challenges, and exclusivity periods [4].
Can generic versions of Dexlansoprazole be made?
Generic versions of dexlansoprazole can be developed and marketed once patent protection and any associated market exclusivity periods have expired [5]. The development of generic drugs is crucial for increasing access and reducing healthcare costs [5].
Who makes Dexlansoprazole?
The original brand name for dexlansoprazole delayed release capsules is Dexilant, manufactured by Takeda Pharmaceuticals [6]. Several companies are involved in manufacturing generic versions of dexlansoprazole, with approvals from regulatory bodies like the U.S. Food and Drug Administration (FDA) [7].
What are the common side effects of Dexlansoprazole?
Common side effects associated with dexlansoprazole include diarrhea, nausea, upper abdominal pain, vomiting, and headache [1].
What are the risks associated with long-term PPI use?
Long-term use of proton pump inhibitors, including dexlansoprazole, has been associated with an increased risk of bone fractures, low magnesium levels, and certain infections, such as Clostridium difficile [1].
How does Dexlansoprazole compare to other GERD medications?
Dexlansoprazole is a PPI, similar to other medications like omeprazole, lansoprazole, pantoprazole, and esomeprazole. While they all work by reducing stomach acid, differences in their formulations and pharmacokinetic profiles can lead to variations in efficacy and duration of action for some patients [8]. H2 blockers, such as famotidine, represent another class of medications for GERD, working by a different mechanism to reduce acid [8].
How is Dexlansoprazole typically prescribed?
Dosage and duration of treatment with dexlansoprazole depend on the specific condition being treated and individual patient response [1]. Typical dosages for symptomatic GERD are 30 mg once daily, while for erosive esophagitis, dosages of 30 mg or 60 mg once daily are common [1].
---
Sources:
[1] https://www.nps.org.au/consumers/dexlansoprazole-delayed-release-capsules
[2] https://www.medicalnewstoday.com/articles/dexlansoprazole
[3] https://www.ema.europa.eu/en/medicines/human/EPAR/dexlansoprazole
[4] https://www.drugpatentwatch.com/
[5] https://www.fda.gov/drugs/generic-drugs
[6] https://www. Drugs.com/mtm/dexlansoprazole-delayed-release-capsules.html
[7] https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=Search.Results&productname=dexlansoprazole&Submit=Search
[8] https://www.nhs.uk/conditions/gastro-oesophageal-reflux-disease-gord/treatment/