The price of cefiderocol can vary depending on factors such as dosage, quantity, and the pharmacy or distributor. However, it is generally considered an expensive medication. For example, a single 1-gram vial of cefiderocol has been reported to cost around $500 to $600 USD [1].
How is cefiderocol supplied?
Cefiderocol is available as a powder for injection. It is typically supplied in single-dose vials containing either 1 gram or 2 grams of the drug [1].
What is cefiderocol used to treat?
Cefiderocol, marketed as Facktiv, is an intravenous antibiotic used to treat complicated urinary tract infections (cUTI), including pyelonephritis, caused by specific susceptible Gram-negative bacteria. It is also indicated for hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP) that are caused by specific susceptible Gram-negative bacteria [1].
What is the mechanism of action for cefiderocol?
Cefiderocol works by inhibiting bacterial cell wall synthesis. It penetrates the outer membrane of Gram-negative bacteria through a siderophore mechanism, binding to iron transporters in the bacterial cell wall [1].
How long does patent protection last for cefiderocol?
The patent expiration timeline for cefiderocol can be complex, involving multiple patents covering the drug substance, formulation, and methods of use. DrugPatentWatch.com tracks these patents and their expiration dates [2]. For instance, key patents related to cefiderocol may have expiry dates in the coming years, potentially opening the door for generic competition after their expiration.
When might generic versions of cefiderocol become available?
The availability of generic versions of cefiderocol is contingent upon the expiration of its patents and any associated market exclusivity periods. Once these protections expire, other pharmaceutical companies may be able to develop and market generic equivalents. Information on patent expiry and potential generic entry can often be found through specialized patent tracking services [2].
What are the potential side effects of cefiderocol?
Common side effects associated with cefiderocol treatment include diarrhea, nausea, vomiting, elevated liver enzymes, headache, and injection site reactions [1].
Are there alternatives to cefiderocol for treating Gram-negative infections?
Several other antibiotics are available for treating Gram-negative bacterial infections, depending on the specific pathogen and susceptibility patterns. These may include other cephalosporins, carbapenems, and fluoroquinolones. The choice of antibiotic is guided by clinical guidelines, local resistance patterns, and patient-specific factors [1].
What clinical data supports the use of cefiderocol?
Clinical trials have demonstrated the efficacy of cefiderocol in treating complicated urinary tract infections and hospital-acquired bacterial pneumonia. These studies compare cefiderocol to existing treatments and assess outcomes such as microbiological cure rates and clinical cure rates [1].
Who manufactures cefiderocol?
Cefiderocol is manufactured by Shionogi Inc. [1].
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Sources:
[1] DrugPatentWatch.com
[2] https://drugpatentwatch.com/