Can Entresto (sacubitril/valsartan) cause low blood pressure?
Yes. Entresto can cause low blood pressure (hypotension), especially when starting treatment or after dose increases. Low blood pressure is listed as a known risk with the drug, and it can be more likely in people with certain baseline conditions or those taking other blood-pressure–lowering medicines [1].
When is the risk highest?
The risk is greatest:
- Early in treatment (right after starting)
- After increasing the dose
- If you already run low on blood pressure, have dehydration, or take other medications that lower blood pressure [1]
What symptoms should you watch for?
Low blood pressure can show up as dizziness, lightheadedness, fainting, or feeling unusually weak—particularly when standing up [1]. Seek urgent care if you faint or have severe symptoms.
Who may be more likely to get hypotension from Entresto?
People may be at higher risk if they have conditions that lower effective blood volume or baseline blood pressure, and if they use additional blood-pressure–lowering drugs. Entresto labeling highlights the importance of monitoring blood pressure and individualizing therapy in patients at risk for hypotension [1].
What should you do if your blood pressure drops?
Don’t stop Entresto on your own. Call your prescriber if you get symptoms of low blood pressure. Clinicians commonly respond by adjusting dose, checking hydration status, and reviewing other blood-pressure medicines [1].
Does hypotension matter for safety?
It can. Symptomatic hypotension may limit tolerability and lead to treatment changes. Monitoring blood pressure and symptoms is important to keep therapy safe [1].
Source
[1] https://www.drugs.com/entresto.html