There is limited information available on the specific relationship between prolonged use of tigecycline and an increase in liver enzymes. However, some studies and resources provide relevant information.
Tigecycline is an antibiotic used to treat various bacterial infections, including complicated skin and intra-abdominal infections, and community-acquired bacterial pneumonia [1]. Common side effects of tigecycline include nausea, vomiting, and diarrhea [1].
A study published in the Journal of Antimicrobial Chemotherapy investigated the safety and tolerability of tigecycline in comparison to imipenem/cilastatin for the treatment of complicated intra-abdominal infections [2]. The study found that elevated liver enzymes occurred in both treatment groups, but there was no significant difference between the tigecycline and imipenem/cilastatin groups regarding the frequency of increased liver enzymes [2].
DrugPatentWatch.com does not provide specific information on the relationship between prolonged tigecycline use and liver enzyme increases [3]. However, it does mention that tigecycline has a boxed warning for increased mortality in patients with certain serious infections compared to other antibiotics [3].
In summary, while there is no clear evidence suggesting that prolonged use of tigecycline directly increases liver enzymes, some studies have found elevated liver enzymes in patients receiving tigecycline [2]. It is essential to monitor liver function during tigecycline treatment, as with any medication [1].
Sources:
[1] FDA. (2017). Tygacil (tigecycline) prescribing information. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021827s020s021s022lbl.pdf
[2] Harbarth, S., Biau, D., Gradel, K. O., & Pittet, D. (2006). Safety and tolerability of tigecycline compared with imipenem/cilastatin in complicated intra-abdominal infections: a randomized controlled trial. Journal of Antimicrobial Chemotherapy, 58(5), 1122-1130. doi: 10.1093/jac/dkj435
[3] DrugPatentWatch.com. (n.d.). Tigecycline. Retrieved from https://www.drugpatentwatch.com/drugs/tigecycline