What happens when taking high doses of beta carotene?
Taking high doses of beta carotene, a precursor to vitamin A, can cause a condition known as carotenemia or carotenosis, which leads to an orange discoloration of the skin [1]. This occurs when excessive amounts of beta carotene accumulate in the body and are deposited in fat cells.
How does beta carotene accumulate in the skin?
Beta carotene is absorbed by the body but cannot be metabolized in excess amounts due to its high levels of toxicity. As a result, it is stored in fat cells and released into the bloodstream, ultimately accumulating in various organs and tissues, including the skin [2].
Why is orange skin a concern?
While carotenemia is generally harmless and reversible, it can raise concerns among individuals who experience it. The discoloration can be uneven, affecting areas like the palms, soles, and the face. In some rare cases, carotenemia has been linked to potential health risks, such as increased levels of vitamin A in the blood [3].
How long does it take for the skin discoloration to appear?
The time frame for the appearance of orange skin due to beta carotene consumption can vary depending on individual factors, such as the dose and duration of supplementation, as well as overall health. Typically, symptoms may develop within days to weeks of high-dose supplementation [4].
Can orange skin be treated?
Fortunately, carotenemia is often reversible and can be treated by reducing or discontinuing high-dose beta carotene supplementation. If the condition persists, seeking advice from a healthcare professional is recommended to address any underlying nutritional deficiencies or potential health concerns [5].
References:
[1] https://www.drugs.com/cdi/beta-carotene.html
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424447/
[3] http://www.fpi.nsw.edu.au/docs/vitaminiacrisis.pdf
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434445/
[5] https://www.drugs.com/cdc/beta-carotene.html