Can Keytruda (pembrolizumab) cause fatigue?
Yes. Fatigue is a known side effect reported with Keytruda (pembrolizumab) and is commonly included among the possible adverse effects in patient and prescribing information.
How to tell if fatigue is from Keytruda or something else
Cancer treatment fatigue can come from several sources, including the cancer itself, other medications, anemia, thyroid problems, infections, or immune-related side effects. Because Keytruda can also trigger immune system inflammation, fatigue that comes with other symptoms should be discussed promptly with the oncology team.
When fatigue should be reported urgently
Contact your clinician right away if fatigue is severe, rapidly worsening, or comes with symptoms that could indicate complications, such as shortness of breath, fainting, chest pain, fever or infection symptoms, severe weakness, or new muscle/joint pain.
What patients usually do to manage fatigue on Keytruda
Clinicians typically evaluate fatigue by checking for treatable causes (for example, blood counts and thyroid function) and adjusting supportive care. Activity pacing, sleep support, and addressing contributing issues (like anemia, dehydration, or medication effects) are common approaches.
Sources:
1. https://www.drugs.com/keytruda.html