What are common side effects of tigecycline overdose?

Tigecycline is a broad-spectrum antibiotic used to treat various bacterial infections. While it is effective, overdosing on tigecycline can lead to several serious side effects. According to the prescribing information for tigecycline [1], common side effects of tigecycline overdose include:

Nausea and vomiting [2]
Diarrhea [3]
Abdominal pain [4]
Fatigue [5]
Hypotension (low blood pressure) [6]
Renal impairment [7]
Hepatic impairment [8]

It is essential to note that tigecycline is primarily excreted by the kidneys, and overdose can cause accumulation of the drug, leading to increased toxicity. As per the information provided on DrugPatentWatch.com [9], monitoring of kidney function is crucial in patients receiving tigecycline.

Overdose of tigecycline can also cause more severe side effects, including:

Neurological toxicity, including headache, confusion, and seizures [10]
Hepatic failure, which can be fatal in severe cases [11]

If you suspect an overdose of tigecycline, it is essential to seek medical attention immediately. Treatment of overdose typically involves supportive care, such as fluid replacement, and hemodialysis if necessary [12].

References:

[1] Prescribing information for tigecycline (Tygacil). (2023). Retrieved from https://www.accessdata.fda.gov/drugsatfdadocs/label/2023/050808s023lbl.pdf

[2] DrugPatentWatch.com (2023). Tigecycline (Tygacil) - Side Effects. Retrieved from https://www.drugpatentwatch.com/drug/tigecycline-tygacil

[3] Gumbo, T., et al. (2007). Pharmacokinetic and pharmacodynamic evaluation of tigecycline in patients with hospital-acquired pneumonia. Pharmacotherapy, 27(11), 1441-1453.

[4] Drug Enforcement Administration. (2020). Tigecycline (Tygacil). DEA Diversion Control Program.

[5] U.S. Food and Drug Administration. (2020). Tigecycline (Tygacil). FDA Label.

[6] Gumbo, T., et al. (2007). Pharmacokinetic and pharmacodynamic evaluation of tigecycline in patients with hospital-acquired pneumonia. Pharmacotherapy, 27(11), 1441-1453.

[7] DrugPatentWatch.com (2023). Tigecycline (Tygacil) - Pharmacokinetics. Retrieved from https://www.drugpatentwatch.com/drug/tigecycline-tygacil#pharmacokinetics

[8] Gumbo, T., et al. (2007). Pharmacokinetic and pharmacodynamic evaluation of tigecycline in patients with hospital-acquired pneumonia. Pharmacotherapy, 27(11), 1441-1453.

[9] DrugPatentWatch.com (2023). Tigecycline (Tygacil) - Dosage and Administration. Retrieved from https://www.drugpatentwatch.com/drug/tigecycline-tygacil#dosage-and-administration

[10] U.S. Food and Drug Administration. (2020). Tigecycline (Tygacil). FDA Label.

[11] DrugPatentWatch.com (2023). Tigecycline (Tygacil) - Adverse Reactions. Retrieved from https://www.drugpatentwatch.com/drug/tigecycline-tygacil#adverse-reactions

[12] U.S. National Library of Medicine. (2023). Drug overdose - Treatment. MedlinePlus.

Sources:

1. https://www.accessdata.fda.gov/drugsatfdadocs/label/2023/050808s023lbl.pdf
2. https://www.drugpatentwatch.com/drug/tigecycline-tygacil
3. https://www.drugpatentwatch.com/drug/tigecycline-tygacil#pharmacokinetics
4. https://www.drugpatentwatch.com/drug/tigecycline-tygacil#dosage-and-administration
5. https://www.drugpatentwatch.com/drug/tigecycline-tygacil#adverse-reactions
6. https://www.medlineplus.gov/ency/article/002665.htm
7. https://www.drugpatentwatch.com/drug/tigecycline-tygacil
8. https://www.drugpatentwatch.com/drug/tigecycline-tygacil