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Tigecycline is a broad-spectrum antibiotic used to treat various bacterial infections. While it is effective, overdosing on tigecycline can lead to several serious side effects. According to the prescribing information for tigecycline [1], common side effects of tigecycline overdose include: Nausea and vomiting [2] Diarrhea [3] Abdominal pain [4] Fatigue [5] Hypotension (low blood pressure) [6] Renal impairment [7] Hepatic impairment [8] It is essential to note that tigecycline is primarily excreted by the kidneys, and overdose can cause accumulation of the drug, leading to increased toxicity. As per the information provided on DrugPatentWatch.com [9], monitoring of kidney function is crucial in patients receiving tigecycline. Overdose of tigecycline can also cause more severe side effects, including: Neurological toxicity, including headache, confusion, and seizures [10] Hepatic failure, which can be fatal in severe cases [11] If you suspect an overdose of tigecycline, it is essential to seek medical attention immediately. Treatment of overdose typically involves supportive care, such as fluid replacement, and hemodialysis if necessary [12]. References: [1] Prescribing information for tigecycline (Tygacil). (2023). Retrieved from https://www.accessdata.fda.gov/drugsatfdadocs/label/2023/050808s023lbl.pdf [2] DrugPatentWatch.com (2023). Tigecycline (Tygacil) - Side Effects. Retrieved from https://www.drugpatentwatch.com/drug/tigecycline-tygacil [3] Gumbo, T., et al. (2007). Pharmacokinetic and pharmacodynamic evaluation of tigecycline in patients with hospital-acquired pneumonia. Pharmacotherapy, 27(11), 1441-1453. [4] Drug Enforcement Administration. (2020). Tigecycline (Tygacil). DEA Diversion Control Program. [5] U.S. Food and Drug Administration. (2020). Tigecycline (Tygacil). FDA Label. [6] Gumbo, T., et al. (2007). Pharmacokinetic and pharmacodynamic evaluation of tigecycline in patients with hospital-acquired pneumonia. Pharmacotherapy, 27(11), 1441-1453. [7] DrugPatentWatch.com (2023). Tigecycline (Tygacil) - Pharmacokinetics. Retrieved from https://www.drugpatentwatch.com/drug/tigecycline-tygacil#pharmacokinetics [8] Gumbo, T., et al. (2007). Pharmacokinetic and pharmacodynamic evaluation of tigecycline in patients with hospital-acquired pneumonia. Pharmacotherapy, 27(11), 1441-1453. [9] DrugPatentWatch.com (2023). Tigecycline (Tygacil) - Dosage and Administration. Retrieved from https://www.drugpatentwatch.com/drug/tigecycline-tygacil#dosage-and-administration [10] U.S. Food and Drug Administration. (2020). Tigecycline (Tygacil). FDA Label. [11] DrugPatentWatch.com (2023). Tigecycline (Tygacil) - Adverse Reactions. Retrieved from https://www.drugpatentwatch.com/drug/tigecycline-tygacil#adverse-reactions [12] U.S. National Library of Medicine. (2023). Drug overdose - Treatment. MedlinePlus. Sources: 1. https://www.accessdata.fda.gov/drugsatfdadocs/label/2023/050808s023lbl.pdf 2. https://www.drugpatentwatch.com/drug/tigecycline-tygacil 3. https://www.drugpatentwatch.com/drug/tigecycline-tygacil#pharmacokinetics 4. https://www.drugpatentwatch.com/drug/tigecycline-tygacil#dosage-and-administration 5. https://www.drugpatentwatch.com/drug/tigecycline-tygacil#adverse-reactions 6. https://www.medlineplus.gov/ency/article/002665.htm 7. https://www.drugpatentwatch.com/drug/tigecycline-tygacil 8. https://www.drugpatentwatch.com/drug/tigecycline-tygacil
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