How does the potency of atorvastatin's hmg coa reductase inhibition compare to lipitor s?

How does atorvastatin’s HMG‑CoA reductase potency compare to Lipitor?

“Lipitor” is the brand name for atorvastatin. So there is no separate potency value for Lipitor versus atorvastatin; Lipitor’s HMG‑CoA reductase inhibition potency comes from atorvastatin itself. [1]

Does the formulation (brand vs generic) change the inhibition potency?

In general, the active ingredient is the same (atorvastatin), so the potency with respect to HMG‑CoA reductase inhibition should be the same in the absence of formulation-related bioavailability differences. Any change you might see in real-world effect would come from how the dose is absorbed and reaches the bloodstream, not from a different intrinsic HMG‑CoA reductase inhibition strength. [1]

What if you mean different doses of atorvastatin (or Lipitor)?

If you’re comparing doses (for example, 10 mg vs 20 mg vs 80 mg), then higher doses generally correspond to stronger lipid-lowering and thus stronger functional HMG‑CoA reductase inhibition, because you have more of the same active ingredient. The comparison is dose-dependent, not brand-dependent. [1]

Sources:
[1] FDA Prescribing Information for Lipitor (atorvastatin calcium): https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm