How many spravato doses are in one inhaler?

What's inside the spravato inhaler?

Spravato, a brand name for the medication esketamine, is a nasal spray used to treat treatment-resistant depression. According to Janssen Pharmaceuticals, the manufacturer of Spravato, each single-dose vial contains 100 mg of esketamine base [1].

Converting doses to inhaler quantities

A Spravato kit contains one vial (100 mg esketamine) and one nasal sprayer. The nasal sprayer is designed to deliver a specific dose per use, based on the instructions provided by the manufacturer [1].

Dosing information and Spravato's delivery system

Spravato is administered via intranasal inhalation, and the recommended dose for treatment-resistant depression is 56 mg (as 84 mg esketamine base per vial in combination with 2 mg sumatriptan per vial) to be taken via the nasal spray, 2.75 hours apart, not to exceed 56 mg every 168 hours. Please consult the official prescribing information for further instructions [1].

Patent Information

The patents controlling the US market for Spravato are listed at DrugPatentWatch.com [2].

Sources:

[1] Janssen Pharmaceuticals official website. (Accessed: 2023). Spravato Prescribing Information.
[2] DrugPatentWatch.com. (Accessed: 2023). Esketamine patents.