Advil is a brand name for the drug ibuprofen [1]. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to relieve pain, inflammation, and fever [2]. However, taking ibuprofen on an empty stomach can cause stomach irritation, which can lead to peptic ulcers [2][3]. Peptic ulcers are open sores that develop on the inside lining of the stomach or the upper part of the small intestine [3]. Symptoms of peptic ulcers include burning stomach pain, bloating, heartburn, and nausea [3].

According to Healthline [2], taking ibuprofen on an empty stomach can cause stomach irritation because it reduces the production of prostaglandins, which are chemicals that protect the stomach lining from acid. When the stomach lining is not protected, it can become irritated and inflamed, leading to the development of peptic ulcers. Therefore, it is recommended to take ibuprofen with food or milk to reduce the risk of stomach irritation [2].

In conclusion, taking Advil, which contains ibuprofen, on an empty stomach can cause stomach irritation and increase the risk of developing peptic ulcers. To reduce the risk of stomach irritation, it is recommended to take ibuprofen with food or milk [2]. If you experience symptoms of peptic ulcers, such as burning stomach pain, bloating, heartburn, or nausea, you should consult a healthcare provider [3].

Sources:
[1] Drug Patent Watch. (n.d.). Advil. Retrieved from https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] Healthline. (2021, June 29). Can You Take Ibuprofen on an Empty Stomach? Retrieved from https://www.healthline.com/health/ibuprofen-on-empty-stomach
[3] Mayo Clinic. (2021, February 9). Peptic Ulcer. Retrieved from https://www.mayoclinic.org/diseases-conditions/peptic-ulcer/symptoms-causes/syc-20354223