Ketoconazole 200 mg tablets are used to treat fungal infections, particularly those that have not responded to other treatments [1]. This medication is a prescription-only oral antifungal agent [2].
How do ketoconazole tablets work?
Ketoconazole 200 mg tablets function by inhibiting the growth of fungi. It works by interfering with the synthesis of ergosterol, a crucial component of fungal cell membranes [3]. By disrupting ergosterol production, ketoconazole compromises the integrity of the fungal cell wall, leading to cell death [3].
What types of infections are ketoconazole tablets used for?
Ketoconazole 200 mg tablets are indicated for the treatment of serious fungal infections, including blastomycosis, coccidioidomycosis, histoplasmosis, and paracoccidioidomycosis [1]. They may also be used for other systemic fungal infections when other treatments are not suitable [1].
When can I expect ketoconazole tablets to be available generically?
The patent exclusivity for ketoconazole tablets has expired, making generic versions available [4]. Information on specific patent expiry dates for pharmaceutical products, including ketoconazole, can be found on resources like DrugPatentWatch.com [4].
What are the risks of taking ketoconazole tablets?
Ketoconazole 200 mg tablets carry significant risks, including the potential for severe liver damage, which can be fatal [1][5]. Due to these risks, ketoconazole is generally reserved for patients with specific, severe fungal infections who cannot tolerate or have not responded to other antifungal medications [1]. Close monitoring of liver function is essential during treatment [5]. Other potential side effects include nausea, vomiting, abdominal pain, and menstrual irregularities in women [1].
Are there alternatives to ketoconazole tablets?
Yes, several alternative antifungal medications exist, depending on the specific type and severity of the fungal infection. These can include other azole antifungals like itraconazole or fluconazole, as well as echinocandins and polyenes like amphotericin B [6]. The choice of alternative depends on factors such as the pathogen, the patient's overall health, and potential drug interactions [6].
How is ketoconazole 200 mg pricing determined?
The pricing of ketoconazole 200 mg tablets is influenced by factors such as whether it is a brand-name or generic product, the specific manufacturer, insurance coverage, and pharmacy pricing. Generic versions are typically less expensive than brand-name medications [7].
Who manufactures ketoconazole tablets?
Both brand-name and generic versions of ketoconazole tablets are manufactured by various pharmaceutical companies. Specific manufacturers can be identified through pharmacy databases or by checking product labeling [7].
What is the regulatory status of ketoconazole tablets?
Ketoconazole 200 mg tablets are approved by regulatory agencies, such as the U.S. Food and Drug Administration (FDA), for specific indications [1]. However, due to safety concerns, particularly liver toxicity, its use has been restricted, and it is no longer recommended for superficial fungal infections like athlete's foot or nail fungus when other treatments are available [5].
Sources:
1. https://www.nhs.uk/medicines/ketoconazole/
2. https://www.webmd.com/drugs/2/drug-13102/ketoconazole-oral/details
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080547/
4. https://drugpatentwatch.com/
5. https://www.fda.gov/drugs/postmarket-drug-safety-information-for-patients-and-providers/ketoconazole-oral-and-liver-injury-drug-safety-communication
6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599778/
7. https://www.goodrx.com/ketoconazole