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See the DrugPatentWatch profile for methotrexate
Is methotrexate's potency affected by using specific OTC drugs? How does ibuprofen change methotrexate levels? Ibuprofen can raise methotrexate levels in the blood by slowing its removal through the kidneys. This effect may lead to higher exposure and possible side effects. Patients on methotrexate for rheumatoid arthritis or cancer sometimes take ibuprofen for pain, but medical supervision is required. How does aspirin affect methotrexate? Aspirin and other salicylates can also increase methotrexate levels by competing for excretion pathways. This combination requires careful monitoring because it can ergot toxicity risks if doses are high.
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