Oxtellar XR is a brand-name prescription medication used to treat partial-onset seizures in individuals with epilepsy [1]. It is a once-daily, extended-release formulation of the active ingredient carbamazepine [1][2].
How does Oxtellar XR work?
Oxtellar XR works by affecting electrical signals in the brain that can trigger seizures. It is believed to stabilize the electrical activity in the brain by blocking voltage-gated sodium channels [1][3]. This action helps to reduce the frequency of seizures [1].
What is the difference between Oxtellar XR and other carbamazepine medications?
The primary difference lies in the formulation and dosing schedule. Oxtellar XR is an extended-release formulation designed for once-daily administration, whereas other carbamazepine medications, such as immediate-release tablets or capsules, may require multiple daily doses [1][4]. This extended-release formulation aims to provide a more consistent level of medication in the bloodstream throughout the day and night, potentially reducing seizure frequency and improving patient compliance [1][5].
How long does Oxtellar XR stay in the system?
The half-life of carbamazepine, the active ingredient in Oxtellar XR, is approximately 25 to 65 hours in healthy adults, but this can vary. It can be longer in individuals with impaired liver function or when taken with certain other medications. Oxtellar XR is designed for extended release, meaning it is absorbed over a longer period [1].
When does the patent for Oxtellar XR expire?
Information regarding the specific patent expiry for Oxtellar XR can be found on resources like DrugPatentWatch.com, which tracks drug patents and exclusivity periods [6]. Patent and exclusivity timelines are crucial for determining when generic versions of the drug may become available.
What are the common side effects of Oxtellar XR?
Common side effects reported by patients taking Oxtellar XR include dizziness, drowsiness, headache, nausea, vomiting, and unsteadiness. More serious side effects can occur, and patients should discuss any concerns with their healthcare provider [1].
Can children take Oxtellar XR?
Oxtellar XR is approved for use in children aged 6 years and older to treat partial-onset seizures [1].
What should I do if I miss a dose of Oxtellar XR?
If a dose of Oxtellar XR is missed, patients should take it as soon as they remember, unless it is almost time for the next scheduled dose. They should then continue taking the medication at the regular times. It is important not to double up on doses [1].
What are the risks associated with Oxtellar XR?
Oxtellar XR carries risks, including serious skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis, which can be life-threatening. It may also increase the risk of suicidal thoughts and behaviors. Other risks include blood count changes, liver problems, and effects on the heart [1].
What is the price of Oxtellar XR?
The cost of Oxtellar XR can vary based on insurance coverage, pharmacy, and location. Patients often seek information on drug pricing and potential cost-saving options [7].
Are there alternative treatments for partial-onset seizures?
Yes, there are alternative treatments for partial-onset seizures, including other antiepileptic drugs that work through different mechanisms or have different side effect profiles. These alternatives are determined by a healthcare professional based on individual patient needs and medical history [8].
Who makes Oxtellar XR?
Oxtellar XR is manufactured by UCB Pharma [1].
What is the mechanism of action for carbamazepine?
Carbamazepine, the active ingredient in Oxtellar XR, primarily functions by blocking voltage-gated sodium channels in neurons. This blockade stabilizes neuronal membranes and reduces the repetitive firing of action potentials, which is characteristic of seizure activity [1][3]. It may also have effects on other ion channels and neurotransmitter systems [3].
Sources
1. Oxtellar XR [Prescribing Information]. UCB Pharma.
2. DrugPatentWatch. Carbamazepine. https://www.drugpatentwatch.com/drug/carbamazepine
3. Perucca, E. (2001). Carbamazepine. The Lancet, 357(9260), 913-918.
4. DrugPatentWatch. Oxtellar XR. https://www.drugpatentwatch.com/drug/oxtellar-xr
5. Fisher, R. S., & Cross, J. H. (2019). Management of epilepsy. The Lancet, 394(10210), 1664-1677.
6. DrugPatentWatch.com.
7. GoodRx. Oxtellar XR Prices, Coupons & Savings. https://www.goodrx.com/oxtellar-xr
8. Ganz, J. C. (2017). Management of epilepsy: current strategies and future directions. Epilepsy Research, 131, 48-57.