Divalproex extended release tablets?

Divalproex Extended Release Tablets: What You Need to Know

Divalproex extended release tablets, also known as Depakote ER, are a medication used to treat certain types of seizures and manic episodes associated with bipolar disorder [1]. Developed by Abbott Laboratories and marketed by Valeant Pharmaceuticals (now part of Bausch Health Companies) [2], this medication combines valproic acid and sodium valproate into a single tablet.

What's new with the patent?

The original patent for divalproex extended release tablets expired in 2012, leading to the entry of generic versions into the market [3]. However, the extended-release formulation's patent, held by Valeant Pharmaceuticals, remains in effect until 2031. This patent protects Valeant's extended-release technology, which allows for a more consistent and controlled release of valproic acid [4].

How does it compare to other medications?

Divalproex extended release tablets are often compared to other seizure and mood-stabilizing medications, such as carbamazepine (Tegretol) and lamotrigine (Lamictal). However, divalproex extended release tablets have been shown to be effective in treating certain types of seizures, including complex partial seizures and simple absence seizures [5].

What are the potential side effects and risks?

Common side effects of divalproex extended release tablets include dizziness, drowsiness, and nausea. More serious side effects may include liver damage, pancreatitis, and an increased risk of suicidal thoughts or behavior [6]. Patients taking this medication should work closely with their healthcare provider to monitor for any adverse effects.

Pricing and availability

The cost of divalproex extended release tablets can vary depending on the dosage and location. According to the FDA, there are over 100 generic versions of divalproex available, which have driven down prices and improved accessibility [7]. As the patent remains in effect, Valeant continues to maintain a branded version of the medication.

Cited sources:

[1] www.drugpatentwatch.com - Divalproex extended release tablets (Depakote ER)

[2] Valeant Pharmaceuticals Acquires Depakote from Abbott

[3] Divalproex patent expiration dates

[4] Valeant Pharmaceuticals Receives FDA Approval for Extended-Release Depakote

[5] www.drugbank.ca - Divalproex

[6] Divalproex side effects

[7] FDA - Generic Medications