What is “liceridine” and what does “spiro” refer to?
“Oliceridine” is the opioid pain medicine oliceridine (a μ-opioid receptor agonist). A request like “Oliceridine patent synthesis spiro” usually points to patent documents that describe how the drug’s chemical structure is built, including “spiro” (spirocyclic) ring systems that appear in some synthetic routes or intermediates.
With only your query text, I can’t identify which specific patent or which “spiro” intermediate you mean (there are different synthetic schemes, intermediates, and claim sets across different filings and jurisdictions).
Which patent should I look for?
The fastest way to find the exact “Oliceridine” spiro synthesis description is to search within patents using any of the following:
- The drug name: “oliceridine”
- The spiro intermediate (if you know its name or scaffold)
- A SMILES/InChI for the spiro ring (if you have it)
- The assignee (often the company that developed oliceridine)
- Patent families (US/EPO/WO) tied to oliceridine’s development
If you share any one of these, I can narrow it to the right patent(s) and the exact spiro-containing step:
- a patent number (e.g., “US…”, “WO…”, “EP…”)
- the assignee name
- a link or screenshot of the relevant patent page
- the spiro intermediate name or SMILES
What does a “spiro” step in a patent synthesis usually involve?
In patent syntheses, “spiro” commonly appears in contexts like:
- forming a spiro ring system via cyclization,
- building a spiro junction from a ketone/aldehyde plus another ring fragment (or vice versa),
- using protected functional groups and ring-closing conditions to generate the spiro center,
- describing stereochemistry if the spiro center is chiral or if the route controls diastereomers.
Different patents can vary widely in reagents, catalysts, and conditions even for the same spiro scaffold.
Are you looking for a reaction scheme or a legal/patent claim?
People search “oliceridine patent synthesis spiro” for two different reasons:
1) Technical chemistry: “How do they make the spiro intermediate?”
2) Freedom-to-operate: “Does a competitor’s spiro route avoid the patent claims?”
Tell me which you want:
- a chemistry-focused description of the spiro-forming step(s) and intermediates, or
- a claims-focused map of what the spiro-related claims cover.
What I need from you to answer precisely
Reply with one of the following so I can give the exact synthesis/patent content you’re looking for:
- the patent number or link
- the assignee and filing year
- the spiro intermediate name (or its structure/SMILES)
- the jurisdiction (US, WO, EP, etc.)
Once you provide that, I can extract and summarize the relevant spiro synthesis portion and explain where it fits in the overall oliceridine preparation.