What are the potential risks of combining Advil with MAOI medication?
Combining Advil (ibuprofen) with monoamine oxidase inhibitor (MAOI) medication can increase the risk of serious side effects, including serotonin syndrome, bleeding, and blood pressure changes. MAOIs, such as phenelzine, are used to treat depression, Parkinson's disease, and certain headaches, by increasing the levels of certain neurotransmitters in the brain [1].
What is serotonin syndrome?
Serotonin syndrome is a potentially life-threatening condition that can occur when there is too much serotonin in the body. Symptoms include agitation, confusion, rapid heartbeat, changes in blood pressure, and even coma or death [2]. Ibuprofen, an NSAID, can increase the levels of serotonin in the body, which can be problematic when taken with MAOIs.
How can bleeding complications occur with Combining Advil and MAOI?
Both ibuprofen and MAOIs can affect platelet function, which can increase the risk of bleeding complications. This is particularly concerning when taking aspirin, another NSAID, with MAOIs, as it can enhance this bleeding risk [3].
Who should monitor their blood pressure when taking Advil and MAOIs?
Patients with hypertension or other cardiovascular conditions should closely monitor their blood pressure when taking ibuprofen with MAOIs. Both medications can raise blood pressure, which may lead to complications such as heart attack, stroke, or kidney damage [4].
Can patients still safely use Advil with MAOIs?
Only under close medical supervision should patients take Advil with MAOIs. Your doctor should carefully weigh the risks and benefits of combining these medications, considering factors such as your medical history, current medications, and health status. [5]
What advice can patients give to others?
If you take MAOIs and are prescribed ibuprofen, inform your doctor, pharmacist, or healthcare provider about any other medications you are taking.
Sources:
[1] U.S. National Library of Medicine. (2022). MAOIs. Retrieved from https://medlineplus.gov/druginfo/meds/a681016.html
[2] MedlinePlus. (2022). Serotonin Syndrome. Retrieved from https://medlineplus.gov/ency/article/000737.htm
[3] UpToDate. (2022). Prevention of bleeding in patients taking anticoagulants, antiplatelet agents, or NSAIDs. Retrieved from https://www.uptodate.com/contents/prevention-of-bleeding-in-patients-taking-anticoagulants-antiplatelet-agents-or-nsaids
[4] Mayo Clinic. (2022). High Blood Pressure. Retrieved from https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/symptoms-causes/syc-20351260
[5] DrugPatentWatch.com. Retrieved from https://www.drugpatentwatch.com/