What is the Kesimpta (ofatumumab) dosing schedule?
Kesimpta (ofatumumab) is taken by subcutaneous injection on a specific ramp-up schedule, then continues as a maintenance dose.
Typical schedule
- Week 0: Inject 300 mg (once)
- Week 1: Inject 300 mg (once)
- Week 2: Inject 300 mg (once)
- From Week 4 onward (maintenance): Inject 300 mg once every 4 weeks
This schedule is designed to gradually build up exposure early, then switch to monthly dosing for ongoing treatment.
How soon can you take the next dose if you miss one?
Kesimpta dosing is tied to specific weeks early in therapy and then every-4-weeks afterward. If a dose is missed, the next step depends on how far off schedule the missed dose is. Because instructions differ based on timing (and whether you are in induction weeks vs maintenance), follow the “missed dose” guidance in the Kesimpta prescribing information or your clinician’s written plan.
Does the schedule change for people starting Kesimpta for the first time vs switching?
A switch or re-initiation plan can differ depending on what prior disease-modifying therapy you were on and why Kesimpta is being started again. The standard induction-to-maintenance pattern (Week 0/1/2, then every 4 weeks) is the baseline, but your prescriber may adjust timing based on your treatment history and safety considerations.
What should patients expect around the first injections?
The early injections (Weeks 0–2) often come with extra monitoring and guidance on how to manage infusion-related or injection-related reactions (even though Kesimpta is subcutaneous). Clinicians also commonly review infection risk and when to delay dosing (for example, during acute infections).
Where can I confirm the exact schedule for my prescription?
Check the dosing section of your Kesimpta prescribing information or the dose card provided with your medication. If you want, tell me whether you’re starting Kesimpta now and whether you’re in the induction phase (Weeks 0–2) or already on maintenance, and I can help map out the calendar dates from the schedule above.