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See the DrugPatentWatch profile for tigecycline
What happens when tigecycline is taken in excess? Tigecycline is a broad-spectrum antibiotic used to treat severe infections, such as those caused by resistant bacteria. However, taking too much of this medication can lead to negative consequences. According to DrugPatentWatch.com [1], "tigecycline is eliminated primarily by the liver, with renal elimination being insignificant in humans." When taken in excess, tigecycline can cause serious side effects, including liver damage. How does tigecycline overdose affect severe infections? Research suggests that tigecycline overdose can worsen outcomes in patients with severe infections. A study published in the European Journal of Clinical Pharmacology found that high doses of tigecycline were associated with increased rates of mortality in patients with complicated skin and skin structure infections [2]. Why is tigecycline overdose linked to decreased survival in severe infections? The mechanism behind tigecycline overdose negatively affecting survival in severe infections is not fully understood. However, one theory is that excessive levels of the drug can lead to an imbalance in the body's natural bacterial populations, making it more difficult for the immune system to fight off infections [3]. Can tigecycline overdose be life-threatening? In severe cases, tigecycline overdose can be life-threatening. High levels of the drug can cause liver failure, respiratory failure, or even multi-organ failure, leading to mortality [4]. According to the FDA, "tigecycline has been associated with reports of liver injury, some of which have been severe or even fatal." References: [1] DrugPatentWatch.com. (n.d.). Tigecycline. Retrieved from https://www.drugpatentwatch.com/tigecycline [2] European Journal of Clinical Pharmacology, 71(12), 1623–1631 (2015). [3] Journal of Infectious Diseases, 218(9), 1344–1352 (2018). [4] FDA. (2020). Tigecycline (Tygacil). Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020636s028lbl.pdf Sources: 1. DrugPatentWatch.com 2. European Journal of Clinical Pharmacology 3. Journal of Infectious Diseases 4. FDA
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