Standard Tigecycline Dosing for Adults
Tigecycline, an intravenous glycylcycline antibiotic, is typically given as a 100 mg loading dose followed by 50 mg every 12 hours for complicated skin/skin structure infections or intra-abdominal infections. Continue for 5-14 days based on infection severity and response.[1]
How Long Does Treatment Last?
Duration varies: 5-14 days for skin infections, up to 14 days for intra-abdominal infections. Shorter courses (e.g., 7-10 days) suffice for many cases; extend only if clinically needed.[1]
Dosing Adjustments for Kidney or Liver Issues
No renal dose adjustment needed, as tigecycline isn't primarily cleared by kidneys. For severe liver impairment (Child-Pugh C), reduce maintenance dose to 25 mg every 12 hours after 100 mg load. Use caution in mild-moderate liver issues.[1]
What If Used in Kids or Special Cases?
Approved for patients 8+ years: same adult dosing by weight (or 1.2 mg/kg load, then 0.6 mg/kg every 12 hours). Not routine for pneumonia or uncomplicated infections due to FDA warnings on mortality risk.[1]
Common Side Effects Patients Report
Nausea (26%), vomiting (18%), diarrhea (13%); often managed with antiemetics. Monitor for superinfections or low blood sugar.[1]
[1]: Tigecycline Prescribing Information (Pfizer)