Lacosamide is an antiepileptic drug used to treat partial-onset seizures in adults with epilepsy. While it is generally considered safe and effective, there are some risks associated with its use, including the potential for lacosamide-induced arrhythmia.

According to a study published in the Journal of the American Heart Association [3], lacosamide has been associated with an increased risk of developing arrhythmia. Specifically, the study found that lacosamide use was associated with a higher risk of developing bradyarrhythmia, which is an abnormally slow heart rate, and atrioventricular block, which is a condition that occurs when the electrical signals that control the heartbeat are disrupted.

The study also found that the risk of developing arrhythmia was higher in patients who were taking higher doses of lacosamide and in those who had pre-existing heart conditions. Therefore, it is important for patients taking lacosamide to be closely monitored by their healthcare provider, especially if they have a history of heart disease or other risk factors for arrhythmia.

Additionally, the drug patent watch website [1] mentions that lacosamide has a black box warning for serious cardiac adverse reactions, including arrhythmia, and advises that the drug should be used with caution in patients with known cardiac conduction problems.

In conclusion, while lacosamide is generally considered safe and effective for the treatment of partial-onset seizures in adults with epilepsy, it is associated with an increased risk of developing arrhythmia, particularly in patients with pre-existing heart conditions or those taking higher doses of the drug. Patients taking lacosamide should be closely monitored by their healthcare provider for signs of arrhythmia, and the drug should be used with caution in patients with known cardiac conduction problems.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LACOSAMIDE
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790938/
[3] https://www.ahajournals.org/doi/10.1161/CIR.0000000000000905