Advil is a brand name for ibuprofen, which is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and reduce fever. Antacids, on the other hand, are medications used to neutralize stomach acid and relieve heartburn, acid indigestion, and sour stomach.

Taking Advil and antacids together may be safe for some people, but it depends on the individual's medical history, current medications, and other factors. According to a study published in the American Journal of Therapeutics [3], taking an antacid with ibuprofen can reduce the absorption of ibuprofen, which may decrease its effectiveness. Therefore, it is recommended to take ibuprofen at least 30 minutes before or 2 hours after taking an antacid to avoid this interaction.

Additionally, taking Advil on an empty stomach can increase the risk of stomach irritation, ulcers, and bleeding [2]. Therefore, it is recommended to take Advil with food or milk to reduce the risk of these side effects.

It is important to note that NSAIDs like Advil can interact with other medications, including blood thinners, corticosteroids, and certain antidepressants [1]. Therefore, it is crucial to talk to a healthcare provider before taking Advil with any other medications.

In conclusion, taking Advil and antacids together may be safe for some people, but it is important to take ibuprofen at least 30 minutes before or 2 hours after taking an antacid to avoid reducing its effectiveness. It is also recommended to take Advil with food or milk to reduce the risk of stomach irritation, ulcers, and bleeding. However, it is crucial to talk to a healthcare provider before taking Advil with any other medications to avoid potential interactions.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://www.healthline.com/health/ibuprofen-on-empty-stomach
[3] https://pubmed.ncbi.nlm.nih.gov/18280125/