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See the DrugPatentWatch profile for keytruda
Keytruda (pembrolizumab) received its initial U.S. FDA approval for unresectable or metastatic melanoma that is progressing after treatment with ipilimumab (Yervoy) and, if BRAF V600 mutation-positive, a BRAF inhibitor.[1]
That first approval was the start of Keytruda’s expansion into additional cancers and settings (later indications added through subsequent FDA approvals). But the original, first-label cancer type was melanoma.[1] Sources: [1] https://www.drugs.com/history/pembrolizumab.html
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