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Gazyva infusions can cause several side effects, with infusion-related reactions being the most common. These reactions can include fever, chills, nausea, rash, headache, and shortness of breath. Some reactions may be severe, requiring interruption or discontinuation of the infusion [1].
What kind of infusion reactions can occur with Gazyva?
Infusion reactions with Gazyva can range from mild to severe. Symptoms may include but are not limited to fever, chills, rash, hives, low blood pressure, and difficulty breathing [1]. These reactions often occur during the infusion or within 24 hours of receiving the drug. Medical professionals monitor patients closely during treatment for these potential reactions [1].
How are Gazyva infusion reactions managed?
To manage infusion reactions, healthcare providers may slow down or temporarily stop the infusion. They might also administer medications such as acetaminophen, antihistamines, or corticosteroids to alleviate symptoms. In cases of severe reactions, Gazyva treatment may need to be permanently discontinued [1].
Are there other potential side effects of Gazyva besides infusion reactions?
Beyond infusion reactions, Gazyva can lead to other side effects. These include a decrease in blood cell counts (neutropenia, anemia, thrombocytopenia), which can increase the risk of infection, bleeding, or fatigue [1]. Additionally, Gazyva can cause diarrhea, cough, fever, and upper respiratory tract infections [1]. Some patients may experience reactivation of hepatitis B virus, which can be serious [1].
What are the risks associated with low blood cell counts from Gazyva?
Low white blood cell counts (neutropenia) increase the risk of serious infections. Low red blood cell counts (anemia) can cause fatigue and shortness of breath. Low platelet counts (thrombocytopenia) can lead to increased bruising or bleeding [1]. Patients are often monitored with blood tests throughout their treatment to detect these changes [1].
What is the risk of hepatitis B reactivation with Gazyva?
Gazyva can cause the reactivation of a past or present hepatitis B infection. This reactivation can lead to liver inflammation (hepatitis) and, in severe cases, liver failure. Patients are screened for hepatitis B before starting Gazyva treatment, and those with a history of the virus may require antiviral therapy during and after treatment with Gazyva [1].
How often are Gazyva infusions given?
The typical Gazyva infusion schedule depends on the specific treatment regimen and the condition being treated. It is often administered intravenously over a period of time, and the frequency of infusions is determined by the prescribing physician [1].
Sources:
[1] https://www.gazyva.com/hcp/important-safety-information/infusion-reactions