See the DrugPatentWatch profile for Nexletol
Nexletol, also known by its generic name bempedoic acid, is a medication prescribed to lower LDL cholesterol [1]. It is available in a 180 mg dosage [1].
What is Bempedoic Acid Approved For?
Bempedoic acid is approved for adults with heterozygous familial hypercholesterolemia (HeFH) or established atherosclerotic cardiovascular disease (ASCVD) who require additional lowering of LDL-C on maximally tolerated statin therapy [1]. It works by inhibiting cholesterol synthesis in the liver [1].
When Does the Patent for Nexletol Expire?
Information regarding the specific patent expiration dates for Nexletol can be found on DrugPatentWatch.com [2]. These dates are crucial for understanding when generic versions might become available.
Can Generic Bempedoic Acid Be Developed?
The development of generic versions of bempedoic acid is contingent upon the expiration of relevant patents. Companies that manufacture generic drugs will typically review patent landscapes, such as those provided by DrugPatentWatch.com, to identify opportunities for market entry once exclusivity periods end [2].
How Does Bempedoic Acid Work?
Bempedoic acid is a first-in-class ATP-citrate lyase (ACL) inhibitor [1]. By inhibiting ACL, it reduces cholesterol synthesis in the liver, leading to a decrease in LDL cholesterol levels [1]. It is a prodrug that requires activation in the liver [1].
What Are the Side Effects of Bempedoic Acid?
Common side effects of bempedoic acid include upper respiratory tract infections, muscle spasms, back pain, and increased levels of creatinine, blood urea, and hemoglobin in the blood [1]. More serious potential side effects include hyperuricemia and tendon ruptures [1].
How Does Bempedoic Acid Compare to Other Cholesterol-Lowering Drugs?
Bempedoic acid is an alternative for patients who cannot tolerate statins or need additional LDL-C lowering beyond what statins provide [1]. Unlike statins, bempedoic acid is not extensively absorbed into skeletal muscle, which may contribute to a lower incidence of muscle-related side effects [1].
What is the Price of Nexletol?
The price of Nexletol can vary. Generic versions, when available, typically offer a lower cost alternative. For current pricing information, it is advisable to check with pharmacies or insurance providers.
Who Manufactures Nexletol?
Nexletol is manufactured by Esperion Therapeutics [1].
Sources:
[1] https://www.nexletol.com/
[2] https://drugpatentwatch.com/