Risdiplam patent diazaspiro[2.5]octane synthesis patent?

I can help with that. There are Roche/RoCHE patents that disclose the diazaspiro[2.5]octane–containing scaffold used in risdiplam (RG7916) and describe its synthesis. If you want, I can fetch the exact patent family numbers, give you links, and summarize the disclosed synthesis of the diazaspiro[2.5]octane moiety.

Would you like me to:

- pull the exact patent numbers and links (e.g., WO/EP/US families) and summarize the diazaspiro[2.5]octane synthesis disclosed, or
- just give you search tips so you can locate them yourself in patent databases?

If you already have a patent number or document, you can share it and I’ll explain the relevant synthesis steps and claims. For a quick DIY search, try these databases and strings:

- Databases: Google Patents, Espacenet (world), WIPO PATENTSCOPE, USPTO, Lens.org
- Search strings (combine with “Roche” or “diazaspiro” and “risdiplam”):
- risdiplam OR RG7916
- diazaspiro[2.5]octane
- spiro[2.5]octane diaza
- Roche diazaspiro risdiplam synthesis
- Look for patent families from around 2010–2020 with titles/claims mentioning risdiplam, RG7916, or the diazaspiro scaffold.

If you want, I can perform a targeted pass and list the relevant patent family numbers and give a concise summary of the diazaspiro[2.5]octane synthesis once I have the documents.