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Apixaban accord?

See the DrugPatentWatch profile for Apixaban

Do you mean Apixaban from Accord Healthcare (a generic version), or just the drug itself (brand-name Eliquis)? If you’re asking about the generic from Accord, it’s the same active ingredient as Eliquis, just a different manufacturer. Here’s a quick overview to help:

What it is
- Apixaban is a direct oral anticoagulant (a DOAC) that inhibits Factor Xa to reduce blood clot formation.

Common indications
- Reduce risk of stroke and systemic embolism in nonvalvular atrial fibrillation.
- Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE).
- Prophylaxis of DVT after hip or knee replacement surgery (preventive use after surgery).

General dosing guidelines (example regimens; exact dose depends on indication and patient factors)
- Atrial fibrillation (nonvalvular): 5 mg twice daily. If the patient has two of the following (age ≥80, weight ≤60 kg, serum creatinine ≥1.5 mg/dL), reduce to 2.5 mg twice daily.
- DVT/PE treatment: 10 mg twice daily for 7 days, then 5 mg twice daily.
- Post-surgical prophylaxis:
- After hip replacement: 2.5 mg twice daily starting 12–24 hours after surgery for 35 days.
- After knee replacement: 2.5 mg twice daily starting 12–24 hours after surgery for 12 days.

Important safety and considerations
- Bleeding risk is the main safety concern; use caution in patients with bleeding risks.
- Not recommended in pregnancy; use in lactation only if benefits outweigh risks (discuss with a clinician).
- Renal function matters: dose adjustments or avoidance in certain levels of kidney impairment.
- Drug interactions: strong inhibitors or inducers of both CYP3A4 and P-gp (e.g., certain antifungals, HIV meds, some antibiotics) can increase or decrease levels of apixaban.
- Do not use if you have a clinically significant active bleed.
- Reversal: Andexanet alfa is approved for reversal of apixaban in life-threatening bleeding; PCC products may be used off-label in some settings—discuss with a clinician.

Availability
- Generic apixaban is available from multiple manufacturers in many regions, including Accord Healthcare. Brand-name Eliquis is still available in many markets.

If you can tell me:
- your country/region
- the indication (AF, DVT/PE, or post-surgery)
- any kidney/hepatic impairment or other meds you’re taking

I can give you more precise dosing and label-specific cautions.



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