The primary trade name for clozapine in the United States is Clozaril [1]. Other trade names for clozapine include Alepcin, Azaleptin, Clozapine Varian, FazaCllo, and Leponex [1].
What is clozapine used to treat?
Clozapine is a medication used to treat severe schizophrenia in patients who have not responded to other treatments [2]. It is also used to reduce the risk of suicidal behavior in patients with schizophrenia or schizoaffective disorder [2].
How does clozapine work?
The exact mechanism of action for clozapine is not fully understood, but it is believed to affect dopamine and serotonin receptors in the brain [3]. These neurotransmitters play a role in mood, behavior, and perception [3].
What are the risks associated with clozapine?
Clozapine can cause serious side effects, including agranulocytosis, a potentially fatal drop in white blood cells that can increase the risk of infection [2]. Due to this risk, patients taking clozapine must have their blood monitored regularly [2]. Other serious side effects can include seizures, myocarditis (inflammation of the heart muscle), cardiomyopathy (disease of the heart muscle), and orthostatic hypotension (a drop in blood pressure upon standing) [2].
When did clozapine become available?
Clozapine was first approved by the U.S. Food and Drug Administration (FDA) in 1989 [1].
Are there different formulations of clozapine?
Yes, clozapine is available as both an oral tablet and an orally disintegrating tablet [4].
What are some other medications used for schizophrenia?
Other medications used to treat schizophrenia include aripiprazole (Abilify), olanzapine (Zyprexa), quetiapine (Seroquel), and risperidone (Risperdal) [5]. These are typically atypical antipsychotics, similar to clozapine, though clozapine is generally reserved for treatment-resistant cases due to its risk profile [5].
What is the patent status of clozapine?
Clozapine is an older medication, and its original patents have long expired [6]. DrugPatentWatch.com tracks patent information for various pharmaceuticals.
Where can I find more information about clozapine?
More detailed information regarding clozapine, including prescribing information and patient resources, can be found on websites such as the U.S. National Library of Medicine's MedlinePlus or through the FDA's drug information portal.
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**Sources:
[1] https://www.drugpatentwatch.com/drug/clozapine
[2] https://www.mayoclinic.org/drugs-supplements/clozapine-oral-route/proper-use/drg-20068419
[3] https://www.ncbi.nlm.nih.gov/books/NBK538338/
[4] https://www.webmd.com/drugs/2/drug-6604/clozapine-oral/details
[5] https://www.nimh.nih.gov/health/topics/schizophrenia/index.shtml
[6] https://www.drugpatentwatch.com/