Based on the provided sources, there is no direct information suggesting that ibuprofen affects the effectiveness of Lipitor (atorvastatin). However, it is important to note that drug interactions can vary depending on individual circumstances and other medications being taken. It is always recommended to consult with a healthcare professional or pharmacist before combining medications.

The first source, Drug Patent Watch, provides information on the patent status of ibuprofen but does not mention any specific interactions with Lipitor or other medications.

The second source, GoodRx, lists potential drug interactions for atorvastatin (Lipitor). It does not mention any specific interaction with ibuprofen. However, it is worth noting that this source provides general information and may not include all possible interactions. It is always best to consult with a healthcare professional for personalized advice.

The third source, the COVID-19 Treatment Guidelines by the National Institutes of Health, discusses the drug-drug interactions of ritonavir-boosted nirmatrelvir (Paxlovid) with other medications. It does not mention any interaction between ibuprofen and Paxlovid or Lipitor.

In conclusion, based on the provided sources, there is no specific evidence suggesting that ibuprofen affects the effectiveness of Lipitor. However, it is always important to consult with a healthcare professional or pharmacist for personalized advice regarding medication interactions.

Sources:
[1] Drug Patent Watch: https://www.drugpatentwatch.com/p/tradename/IBUPROFEN
[2] GoodRx: https://www.goodrx.com/atorvastatin/interactions
[3] COVID-19 Treatment Guidelines - NIH: https://www.covid19treatmentguidelines.nih.gov/therapies/antivirals-including-antibody-products/ritonavir-boosted-nirmatrelvir--paxlovid-/paxlovid-drug-drug-interactions/