Partial
Partially Aligned
Patient Risk:
Medium
Summary
Most core claims (indications, IL-17A mechanism, avoiding live vaccines) align with the provided label excerpts, but several interaction claims (specific interacting drug classes/named drugs including immunosuppressants, antidepressants/anxiolytics, BP meds, diabetes meds, antihistamines) are not supported by the provided prescribing information. Additional claims about immune system weakening and vaccine response wording exceed what is explicitly supported in the excerpts.
Category Scores
Accurate Statements
Cosentyx (secukinumab) is used to treat plaque psoriasis.
1.1 Plaque Psoriasis
Cosentyx (secukinumab) is used to treat psoriatic arthritis.
1.2 Psoriatic Arthritis
Cosentyx (secukinumab) is used to treat ankylosing spondylitis.
1.3 Ankylosing Spondylitis
Cosentyx works by blocking interleukin-17A (IL-17A).
12.1 Mechanism of Action (selectively binds to IL-17A cytokine and inhibits interaction with IL-17 receptor)
Live vaccines should be avoided while taking Cosentyx.
5.7 Immunizations (Avoid use of live vaccines in patients treated with COSENTYX)
Cosentyx is associated with an inability to respond to live vaccines.
12.2 Pharmacodynamics / Immune Response to Non-Live Vaccines section provided does not explicitly mention live-vaccine nonresponse; however 5.7 supports immune response alteration and avoidance of live vaccines.
M-M-R is a live vaccine mentioned as one to avoid while taking Cosentyx.
Not supported by the provided excerpts.
Unsupported Statements
Cosentyx can weaken the immune system.
The provided excerpts state COSENTYX may increase risk of infections and may alter immune response to live vaccines, but do not explicitly support the phrasing 'can weaken the immune system.'
Cosentyx is associated with an inability to respond to live vaccines.
Provided excerpt explicitly says to avoid live vaccines and that COSENTYX may alter immune response to live vaccines, but does not explicitly state 'inability to respond' in the supplied label text.
M-M-R is a live vaccine mentioned as one to avoid while taking Cosentyx.
The provided excerpts do not list M-M-R by name.
Varicella (chickenpox) is a live vaccine mentioned as one to avoid while taking Cosentyx.
The provided excerpts do not list varicella by name.
OPV (oral poliovirus vaccine) is a live vaccine mentioned as one to avoid while taking Cosentyx.
The provided excerpts do not list OPV by name.
Cosentyx may interact with other biologic medications.
The provided drug-interactions excerpt only discusses monitoring with CYP450 substrates; no biologic-biologic interaction guidance is included in the supplied text.
Humira (adalimumab) is listed as another biologic medication that may interact with Cosentyx.
No such agent is mentioned in the provided excerpts.
Enbrel (etanercept) is listed as another biologic medication that may interact with Cosentyx.
No such agent is mentioned in the provided excerpts.
Remicade (infliximab) is listed as another biologic medication that may interact with Cosentyx.
No such agent is mentioned in the provided excerpts.
Cosentyx may interact with immunosuppressant medications.
No immunosuppressant interaction statement is included in the provided excerpts.
Imuran (azathioprine) is listed as an immunosuppressant medication that may interact with Cosentyx.
No such agent is mentioned in the provided excerpts.
Cellcept (mycophenolate mofetil) is listed as an immunosuppressant medication that may interact with Cosentyx.
No such agent is mentioned in the provided excerpts.
Cosentyx may interact with medications for depression and anxiety.
No such interaction is included in the provided excerpts.
Prozac (fluoxetine) is listed as a depression/anxiety medication that may interact with Cosentyx.
No such agent is mentioned in the provided excerpts.
Xanax (alprazolam) is listed as a depression/anxiety medication that may interact with Cosentyx.
No such agent is mentioned in the provided excerpts.
Cosentyx may interact with medications for high blood pressure.
No such interaction is included in the provided excerpts.
Lisinopril (Zestril) is listed as a high blood pressure medication that may interact with Cosentyx.
No such agent is mentioned in the provided excerpts.
Amlodipine (Norvasc) is listed as a high blood pressure medication that may interact with Cosentyx.
No such agent is mentioned in the provided excerpts.
Cosentyx may interact with medications for diabetes.
No such interaction is included in the provided excerpts.
Metformin (Glucophage) is listed as a diabetes medication that may interact with Cosentyx.
No such agent is mentioned in the provided excerpts.
Lantus (insulin glargine) is listed as a diabetes medication that may interact with Cosentyx.
No such agent is mentioned in the provided excerpts.
Cosentyx may interact with medications for allergies.
No such interaction is included in the provided excerpts.
Benadryl (diphenhydramine) is listed as an allergy medication that may interact with Cosentyx.
No such agent is mentioned in the provided excerpts.
Zyrtec (cetirizine) is listed as an allergy medication that may interact with Cosentyx.
No such agent is mentioned in the provided excerpts.
Taking Cosentyx with other biologics is not recommended.
Not supported by the provided excerpts.
Taking Cosentyx with other biologics may increase the risk of adverse effects.
Not supported by the provided excerpts.
Taking Cosentyx with immunosuppressants is not recommended.
Not supported by the provided excerpts.
Taking Cosentyx with immunosuppressants may increase the risk of infections.
Not supported by the provided excerpts.
Taking Cosentyx with depression/anxiety medications may require talking to a doctor or pharmacist about potential interactions and monitoring for side effects.
No specific interaction guidance with these medication categories is present in the provided excerpts.
Taking Cosentyx with high blood pressure medications may require talking to a doctor or pharmacist about potential interactions and monitoring for side effects.
No specific interaction guidance with these medication categories is present in the provided excerpts.
Taking Cosentyx with diabetes medications may require talking to a doctor or pharmacist about potential interactions and monitoring for side effects.
No specific interaction guidance with these medication categories is present in the provided excerpts.
The response to taking Cosentyx and another medication should include monitoring for side effects such as increased risk of infections or allergic reactions.
The label supports increased infection risk and hypersensitivity reactions, but it is not supported in the provided excerpts that 'response to taking Cosentyx and another medication' specifically requires this monitoring statement.
Contradictions
Important Omissions
For live vaccine avoidance, the label excerpt provided supports avoiding live vaccines generally and that COSENTYX may alter immune response to live vaccines, but the AI did not restrict the details to the label’s level of specificity (e.g., it named vaccines not shown in the provided excerpts).
Importance:
Low
Drug interaction content in the provided excerpts is limited to CYP450 substrates monitoring (initiation/discontinuation in patients receiving concomitant CYP450 substrates). The AI did not align interactions to this scope.
Importance:
Moderate
Safety Assessment
Potential Patient Risk:
Medium
Several claims about specific drug interactions and recommendations (e.g., avoiding other biologics/immunosuppressants; interactions with named drugs across multiple categories) are unsupported by the supplied label excerpts, which could mislead decisions. Live vaccine avoidance aligns with the label excerpt.
Regulatory Assessment
| On Label |
No |
| Off-label Discussion |
No |
| Promotes Unapproved Use |
No |
| Hallucination Risk |
Medium |
Recommendation
Partially Aligned
Primary Issue
Drug interaction claims and named drug examples are not supported by the provided prescribing information excerpts; the live-vaccine 'which vaccines' details are also not supported in the excerpts.
Suggested Improvement
Limit interaction statements to the supplied label scope (CYP450 substrate monitoring guidance) and avoid naming specific vaccines/medications unless explicitly present in the provided COSENTYX label text.