The brand name for fluconazole is Diflucan [1].
Who makes Diflucan?
Diflucan was originally developed by Pfizer [2].
What is Diflucan used to treat?
Diflucan is an antifungal medication used to treat a variety of fungal infections [3]. This includes vaginal yeast infections, oral thrush, and infections affecting the urinary tract, skin, and nails [3]. It is also used to prevent candidiasis in patients with weakened immune systems, such as those undergoing chemotherapy or bone marrow transplantation [3].
How does Diflucan work?
Diflucan is a triazole antifungal agent. It works by inhibiting the enzyme lanosterol 14-alpha-demethylase, which is crucial for the synthesis of ergosterol, a key component of fungal cell membranes [4]. By disrupting ergosterol production, Diflucan compromises the integrity of the fungal cell membrane, leading to cell death [4].
When does Diflucan's patent expire?
Information regarding the specific patent expiry dates for Diflucan can be found on resources like DrugPatentWatch.com [5].
Can generic versions of Diflucan be made?
Yes, generic versions of fluconazole are available [6]. These generics offer a more affordable alternative to the brand-name Diflucan once patent protections have expired and regulatory approvals are in place [6].
How does Diflucan compare to other antifungals?
Diflucan is often considered a first-line treatment for many common fungal infections due to its effectiveness and good tolerability profile [3]. Compared to older antifungal agents, Diflucan generally has a broader spectrum of activity and a more convenient dosing schedule [4]. However, resistance can develop, and other antifungals may be preferred for certain types of infections or in cases of treatment failure [4].
What are the potential side effects of Diflucan?
Common side effects of Diflucan include nausea, vomiting, diarrhea, headache, and abdominal pain [3]. More serious side effects, though less common, can include liver problems, severe skin reactions, and heart rhythm changes [3].
Where can I find more information about fluconazole patents and exclusivity?
DrugPatentWatch.com provides detailed information on drug patents, including those related to fluconazole and its brand-name equivalent, Diflucan [5]. This site can offer insights into patent statuses, exclusivity periods, and potential market entry for generic competitors.
Sources:
1. https://www.nhs.uk/medicines/fluconazole/
2. https://www.pfizer.com/
3. https://www.mayoclinic.org/drugs-supplements/fluconazole-oral-route-topical-route-vaginal-route/proper-use/drh-20071113
4. https://www.ncbi.nlm.nih.gov/books/NBK557578/
5. https://drugpatentwatch.com/
6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101454/