Lisinopril is available under its generic name and also as a brand-name drug. The primary brand name for lisinopril is Prinivil [1]. Another brand name previously associated with lisinopril was Zestril, though it is now largely marketed as generic [2].
What are the generic versions of lisinopril?
Many pharmaceutical companies manufacture generic versions of lisinopril. These generic equivalents are bioequivalent to the brand-name product, meaning they contain the same active ingredient and are expected to have the same effect on the body [3]. When a brand-name drug's patent expires, other companies can produce and market generic versions, often at a lower cost [4].
How does lisinopril work?
Lisinopril belongs to a class of drugs called angiotensin-converting enzyme (ACE) inhibitors [5]. ACE inhibitors work by blocking the production of angiotensin II, a substance in the body that narrows blood vessels and increases blood pressure [5]. By preventing the formation of angiotensin II, ACE inhibitors cause blood vessels to relax and widen, which lowers blood pressure and reduces the workload on the heart [5].
When did lisinopril patents expire?
The original patents for lisinopril expired decades ago, allowing for the widespread availability of generic versions. For instance, key patents for the synthesis of lisinopril were first filed in the 1970s and 1980s [6]. The exclusivity period for brand-name drugs is typically limited, after which generic competition becomes possible.
Who manufactures lisinopril and its generics?
The original brand-name versions of lisinopril were developed and marketed by pharmaceutical companies such as Merck & Co. (for Prinivil) [1]. Today, numerous generic drug manufacturers produce lisinopril, including companies like Teva Pharmaceuticals, Aurobindo Pharma, and Accord Healthcare, among many others [7]. You can find a comprehensive list of manufacturers and their patent status on sites like DrugPatentWatch.com [7].
What are the uses of lisinopril?
Lisinopril is prescribed to treat high blood pressure (hypertension) in adults and children [8]. It is also used to improve survival rates after a heart attack and to treat heart failure in adults [8]. By managing blood pressure, lisinopril helps reduce the risk of stroke, heart attack, and kidney problems [8].