Irbesartan/hydrochlorothiazide viatris 300 mg/25 mg generic coaprovel sanofi?

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Accepted Answer

Irbesartan / Hydrochlorothiazide 300 mg / 25 mg
(also sold as the branded product Co‑Prosell® (Sanofi) and as the Viatris generic)


Class	Angiotensin‑II receptor blocker (ARB) + thiazide diuretic
Common brand name	Co‑Prosell® (Sanofi)
Generic	Irbesartan / Hydrochlorothiazide 300 mg / 25 mg (Viatris, other manufacturers)
Form	Oral tablet, once daily

Indication	Typical goal
Hypertension	Lower and maintain blood pressure
Heart failure (stable)	Reduce hospitalizations and improve symptoms
Renal protection in diabetic nephropathy	Slow progression of kidney disease
Combination therapy	When monotherapy (ARB or diuretic alone) isn’t enough

The drug is usually started at the full 300 mg / 25 mg dose and titrated only if needed (e.g., if blood pressure remains above target).

Irbesartan blocks the AT1 receptor for angiotensin‑II, preventing vasoconstriction, aldosterone release, and sodium/water retention.
Hydrochlorothiazide inhibits the Na⁺/Cl⁻ symporter in the distal tubule, promoting natriuresis and diuresis.
The combination provides a synergistic antihypertensive effect.

Category	Details
Contraindications	• Pregnancy (category X) – teratogenic • Severe renal impairment oruria • Known hypersensitivity to ARBs or thiazides
Important warnings	• Hyperkalemia (especially with other K‑retaining agents) • Hypotension (especially in volume‑depleted patients) • Gout or kidney stones (HCTZ)
Drug interactions	• Other antihypertensives (ACE inhibitors, ARBs) → additive hypotension • NSAIDs → reduced diuretic efficacy & possible renal impairment • Lithium, digoxin → ↑ blood levels • Potassium‑sparing diuretics, K⁺ supplements, salt substitutes → ↑ K⁺ risk
Monitoring	• Blood pressure & pulse 1–2 weeks after start and after dose changes • Serum creatinine & electrolytes (K⁺, Na⁺, Cl⁻) at baseline, 4–6 weeks, and periodically thereafter • Urine output in the first week (if at risk of volume depletion)

Symptom	Frequency (≈)
Dizziness / light‑headedness	5–10 %
Headache	5 %
Hyperkalemia (serum K⁺ > 5.5 mmol/L)	1–3 %
Hypotension (especially post‑prandial or standing)	< 2 %
Hyperglycemia (rare)	< 1 %
Gout flare (due to HCTZ)	1–2 %
Rash / pruritus	< 1 %
Angioedema	Rare (1 / 100,000)

If you notice swelling of the face, lips, tongue, or throat, or severe breathing difficulty, seek emergency care immediately.

Pregnancy: Teratogenic; avoid from conception onward.
Lactation: Irbesartan and HCTZ are excreted in breast milk; generally contraindicated in nursing mothers.

Take orally with water once daily, preferably at the same time each day.
Do not split or crush the tablet; it is a fixed‑dose combination.
If you miss a dose, take it as soon as you remember—skip the next dose. Do not double dose.

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