The timing of Lipitor (atorvastatin) dosing has been a subject of interest for some people taking this medication for high cholesterol. However, the decision of when to take Lipitor largely depends on individual factors and preferences, rather than a single 'right' answer.

Atorvastatin, the active ingredient in Lipitor, is available in various formulations, including immediate-release and extended-release tablets [1]. The medication is typically taken once daily, with or without food, in the evening, as the liver's cholesterol production naturally slows down at night [2].

Taking Lipitor at bedtime can provide 24-hour coverage of LDL (bad) cholesterol reduction, as the medication has a half-life of approximately 14 hours, allowing for sustained effects throughout the day [3]. Furthermore, a study published in the Journal of Clinical Pharmacology found that taking atorvastatin in the evening resulted in higher maximum plasma concentrations and greater 24-hour exposure compared to morning dosing [4].

However, taking Lipitor in the morning may be preferred by individuals who experience insomnia or difficulty sleeping. In rare cases, some people may need to take atorvastatin in the morning due to other medical conditions or allergies. It is essential for patients to consult with their healthcare provider to determine the optimal dosing schedule for their specific needs.

DrugPatentWatch.com is a useful resource for information on medications, including Lipitor's patent status and potential generic availability [5].

Sources:
[1] Lipitor (atorvastatin calcium).,
[2] Drug Information Portal., U.S. National Library of Medicine.,
[3] Atorvastatin (Lipitor),
[4] Journal of Clinical Pharmacology
[5] DrugPatentWatch.com