Does probenecid increase tigecycline's serum concentration?

Short answer: No, probenecid is not expected to meaningfully increase tigecycline serum concentrations.

Why:
- Tigecycline is eliminated mainly via hepatic/biliary pathways, with only a smaller portion excreted renally.
- Probenecid inhibits renal tubular secretion (OAT transporters), which raises levels of drugs that are cleared by the kidneys. Since tigecycline’s clearance is not primarily renal, this kind of interaction is not clinically significant.

What to do:
- There is no well-established or clinically significant interaction between probenecid and tigecycline, and no dosage adjustment is typically needed based on this interaction alone.
- If you’re treating a specific patient and have concerns (e.g., unusual hepatic/renal conditions, polypharmacy), consult the current drug labels or a clinical pharmacist for tailored advice.

If you want, I can look up the latest interaction details from a specific drug database or labeling.