What does NCT00046527 test, and where does Abraxane (nab-paclitaxel) fit?
NCT00046527 is a clinical trial record for Abraxane (nab-paclitaxel). The key endpoint you’re asking about, time to progression (TTP), is the amount of time from treatment start until a patient’s disease progresses (or, depending on the protocol, until progression is first documented). Time to progression is often reported as a median value and/or using time-to-event survival methods.
How is “time to progression” (TTP) usually defined in Abraxane trials?
In trials that report TTP, “progression” is typically determined by a prespecified imaging/clinical assessment method (commonly RECIST-style criteria). “Time to progression” is measured from the start of therapy to the first date when progression is confirmed. If a participant does not have documented progression by the analysis cutoff, they may be censored at the last evaluable assessment.
The exact TTP definition for NCT00046527 (for example, whether it is “confirmed” progression versus first progression, and which criteria are used) depends on the trial’s protocol and reporting language.
What TTP results are reported for NCT00046527?
To give the specific TTP number(s) reported for NCT00046527, I would need the trial results text (or the associated publication) because NCT identifiers can point to protocols without the TTP results being present in the summary view.
If you paste the results section (or tell me the cancer type/arm and the publication link you’re using), I can extract the TTP outcome precisely (e.g., median TTP, hazard ratio, confidence intervals).
Are you looking for TTP, progression-free survival (PFS), or overall survival (OS)?
Many oncology trials use either:
- Time to progression (TTP), or
- Progression-free survival (PFS), which is similar but often defined from a randomization/treatment start date to progression or death.
If you tell me whether the trial publication calls the endpoint “TTP” or “PFS,” I can align the interpretation to the correct endpoint wording.
Where can you verify TTP for this specific trial?
The most reliable place to verify trial-reported TTP is the clinical trial record’s “Results” section and any linked publications. If you want, share what you see under NCT00046527 “Results,” and I’ll convert it into a clear TTP statement (median time, comparator arm, and effect size if reported).